Mechanistic Study on the Possible Role of Embelin in Treating Neurodegenerative Disorders.
- Anika et al (2024).
- CNS Neurol Disord Drug Targets.
- PubMed:
- 36655531
Baicalin, a compound found in Scutellaria baicalensis Georgi, has been reported to have antidepressant effects. In this study, the researchers investigated how it works by exploring the role of the PARP1 signaling pathway in depression. They found that administration of baicalin alleviated depressive-like behaviors induced by chronic stress in mice by reducing neuronal damage in the hippocampus and increasing anti-apoptotic proteins while decreasing pro-apoptotic proteins. They also found that baicalin works by regulating the SIRT1/PARP1 signaling pathway. These findings suggest that baicalin may be a potential therapeutic option for depression.
Research has revealed potential herbal medicines for treating mild mood disorders, but with unclear active components. The microbiota-gut-brain axis offers new avenues for treatment and prevention of mood disorders.
Curcumin, a natural compound found in turmeric, was investigated for its potential to reduce opioid dependence in rats. The study used immunofluorescence staining and ELISA methods to evaluate cytokine levels, and western blotting to evaluate the expression of μ-opioid receptors. Results showed that curcumin administration significantly attenuated the symptoms of morphine withdrawal syndrome and reduced cytokine levels and inflammation in the prefrontal cortex. Additionally, the expression of μ-opioid receptors was reduced by curcumin. This study highlights the potential of curcumin as a treatment for opioid dependence by targeting neuroinflammation.
The study examined the effects of ethanol seed extract of Cajanus cajan (CC) on mice that mimic antidepressant and anxiety-like properties. The seeds of CC have traditionally been used in alternative medicine for treating neurological disorders and anxiety. The study could lead to future development of CC-based therapies for these disorders.
Researchers investigated the molecular mechanism behind the popular herbal medicine Dengzhan shengmai (DZSM) formula, which is commonly used to aid recovery from ischemic cerebrovascular diseases. The formula is composed of four herbal medicines and the study found that it promotes angiogenesis, which improves blood flow and aids in the recovery process. The study provides valuable insight into the potential benefits of traditional herbal medicines in treating vascular diseases.
To avoid economic damage to the wine industry, accurate identification of grapevine cultivars is crucial. Researchers have developed morphological, molecular, and chemical tools for positive identification of grape varieties.