Neuroscience Studies

Silibinin ameliorates STING-mediated neuroinflammation via downregulation of ferroptotic damage in a sporadic Alzheimer's disease model.

Silibinin, extracted from Silybum marianum, protects against ferroptotic damage and neuroinflammation in a sporadic AD model by regulating key proteins and pathways.

Neuroscience Silybum marianum
Liu P et al (2023).
Arch Biochem Biophys.
DOI:
10.1016/j.abb.2023.109691
PubMed:
37473980

Nicotine Free Herbal Composition for Smoking De-Addiction - A Placebo Controlled, Double Blind, Randomized, Multicentric Clinical Study.

Study evaluated the effects of a nicotine-free herbal formulation on smoking cessation and related health parameters. Quitting smoking is crucial to prevent various health problems, and this study explores alternative methods.

Neuroscience Mucuna pruriens
Tamoli SM et al (2023).
J Pharm Bioallied Sci.
DOI:
10.4103/jpbs.jpbs_647_21
PubMed:
37469645

Anti-Amyloid β Aggregation Activity and Cell Viability Effect of Betacyanins from Red Pitahaya (Hylocereus polyrhizus) for Alzheimer's Disease.

Betacyanins from red pitahaya have anti-Aβ aggregation activity, with betanin, phyllocactin, and hylocerenin showing the highest activity. These compounds could potentially be used to protect against Alzheimer's disease.

Neuroscience Beta vulgaris
Thwe PN, Yeong KY and Choo WS (2023).
Plant Foods Hum Nutr.
DOI:
10.1007/s11130-023-01081-7
PubMed:
37466824

Neuroprotective effects of Petiveria alliacea on scopolamine-induced learning and memory impairment mouse model.

Researchers studied the medicinal plant Petiveria alliacea L., commonly used in the Caribbean and Central America to treat central nervous system issues like poor memory.

Neuroscience Petiveria alliacea
Zavala-Ocampo LM et al (2023).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2023.116881
PubMed:
37460029

Inhibition mechanisms of four ellagitannins from terminalia chebula fruits on acetylcholinesterase by inhibition kinetics, spectroscopy and molecular docking analyses.

Four ellagitannins from Terminalia chebula fruits inhibit acetylcholinesterase (AChE), a target for Alzheimer's treatment. They cause structural changes in AChE, making them potential natural inhibitors for Alzheimer's.

Neuroscience Terminalia chebula
Li YJ et al (2023).
Spectrochim Acta A Mol Biomol Spectrosc.
DOI:
10.1016/j.saa.2023.123115
PubMed:
37453379

Tetrastigma hemsleyanum suppresses neuroinflammation in febrile seizures rats via regulating PKC-δ/caspase-1 signaling pathway.

T. hemsleyanum has a long history in China for preventing and treating FS. Understanding its mechanisms can provide insights for potential therapeutic approaches.

Neuroscience Tetrastigma hemsleyanum
Ji W et al (2023).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2023.116912
PubMed:
37451489

Papaver rhoeas L. stem and flower extracts: Anti-struvite, anti-inflammatory, analgesic, and antidepressant activities.

L. () plant extracts have anti-struvite, anti-inflammatory, analgesic, and antidepressant effects, containing secondary metabolites that inhibit struvite crystal formation. Promising for pharmaceutical use due to bioactive properties.

ImmunologyNeurosciencePain Papaver rhoeas
Hmamou A et al (2023).
Saudi Pharm J.
DOI:
10.1016/j.jsps.2023.06.019
PubMed:
37448842

Ashwagandha- Withania somnifera (L.) Dunal as a multipotent neuroprotective remedy for genetically induced motor dysfunction and cellular toxicity in human neurodegenerative disease models of Drosophila.

Ashwagandha, an Ayurvedic plant, has therapeutic properties but lacks studies using genetic models of diseases to validate its effectiveness in treating cancer, diabetes, inflammation, and neurodegenerative diseases.

Neuroscience Withania somnifera
Murthy MN and Shyamala BV (2023).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2023.116897
PubMed:
37442493
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