Neuroscience Studies

Dried Loquat Fruit Extract Containing Chlorogenic Acid Prevents Depressive-like Behaviors Induced by Repeated Corticosteroid Injections in Mice.

The study found that a fruit extract from the loquat tree, containing chlorogenic acid, reduced depressive-like behaviors and anxiety in mice. It suggests the potential of this extract as a therapy for depression.

Lim DW, Yoo G and Lee C (2023).
Molecules.
PubMed:
37513484

Anti-Helicobacter pylori, Antioxidant, Antidiabetic, and Anti-Alzheimer's Activities of Laurel Leaf Extract Treated by Moist Heat and Molecular Docking of Its Flavonoid Constituent, Naringenin, against Acetylcholinesterase and Butyrylcholinesterase.

This study found that moist heat treatment of laurel leaf extract increases the concentration of certain beneficial compounds and enhances its antioxidant, anti-diabetic, and anti-Alzheimer's activities.

Al-Rajhi AMH et al (2023).
Life (Basel).
PubMed:
37511887

Modulation of the Proliferative Pathway, Neuroinflammation and Pain in Endometriosis.

Administration of the natural compound AR reduced the size and histological morphology of endometriosis lesions in an in vivo model. AR also reduced hyperproliferation, restored the impaired apoptosis pathway, and exhibited antioxidant, anti-inflammatory, and pain-reducing effects.

Interdonato L et al (2023).
Int J Mol Sci.
PubMed:
37511500

Inhibition of α-Amylase, α-Glucosidase, Pancreatic Lipase, 15-Lipooxygenase and Acetylcholinesterase Modulated by Polyphenolic Compounds, Organic Acids, and Carbohydrates of Prunus domestica Fruit.

Researchers analyzed 43 cultivars and found that polyphenols in fruit had antioxidant activity, inhibited certain enzymes, and had health-promoting benefits. Worth including in diet.

Rybak M and Wojdyło A (2023).
Antioxidants (Basel).
PubMed:
37507919

Glabridin mitigates TiO(2)NP induced cognitive deficit in adult zebrafish.

Glabridin, extracted from Glycyrrhiza glabra, protects zebrafish brains from the negative effects of Titanium dioxide nanoparticles by reducing oxidative stress and inflammation. This suggests glabridin has potential neuroprotective properties.

Kaur K, Narang RK and Singh S (2023).
Neurochem Int.
PubMed:
37499946

Flavonoids from Seabuckthorn (Hippophae rhamnoides L.) restore CUMS-induced depressive disorder and regulate the gut microbiota in mice.

Seabuckthorn, rich in flavonoids, treats depression in mice by regulating neurochemical levels, reducing inflammation, and modulating gut microbiota. Potential health food supplement for major depressive disorders.

Xia CX et al (2023).
Food Funct.
PubMed:
37485660

Simultaneous estimation of five biomarkers of neuroprotective herb Ashwagandha NMITLI-118R AF1 in rat plasma and brain using LC-ESI-MS/MS: Application to its pharmacokinetic and stability studies.

Researchers developed and validated a method to measure biomarkers in a popular supplement. The method is sensitive, accurate, and efficient, providing valuable information for future studies and trials.

Dadge SD et al (2023).
J Chromatogr B Analyt Technol Biomed Life Sci.
PubMed:
37481788