Neuroscience Studies

Co-administration of Ceratonia siliqua extract nanoparticles promotes the oral bioavailability and neurotherapeutic efficacy of donepezil in a dementia model.

Researchers studied how carob extract and silver nanoparticles loaded with carob extract interact with the drug donepezil-HCl in treating dementia. Important for understanding potential herb-drug interactions in dementia treatment.

Neuroscience Ceratonia siliqua
Shaker SE et al (2024).
J Pharm Pharmacol.
DOI:
10.1093/jpp/rgae094
PubMed:
39046816

Integration of High-Resolution LC-Q-TOF Mass Spectrometry and Multidimensional Chemical-Biological Analysis to Detect Nanomolar-Level Acetylcholinesterase Inhibitors from Different Parts of Zanthoxylum nitidum.

Study analyzed Zanthoxyli radix tea components for Alzheimer's. Root has strongest AChE inhibition. Nitidine, chelerythrine, and sanguinarine are key compounds. Potential for new treatments.

Neuroscience Zanthoxylum nitidum
Zhang JN et al (2024).
J Agric Food Chem.
DOI:
10.1021/acs.jafc.4c00866
PubMed:
39045647

Exploring the multifaceted therapeutic mechanism of Schisanlactone E (XTS) in APP/PS1 mouse model of Alzheimer's disease through multi-omics analysis.

Schisanlactone E (XTS) from Tujia medicine shows promise in treating Alzheimer's with anti-inflammatory and antioxidant properties. Study aims to understand XTS's therapeutic effects.

Neuroscience Kadsura heteroclita
Song Z et al (2024).
Front Microbiol.
DOI:
10.3389/fmicb.2024.1440564
PubMed:
39044957

Efficacy of a Novel Nanohydrogel Formulation Containing Dopamine, Chitosan Nanoparticles, and Tridax procumbens Extract for Enhanced Wound Healing in Human Gingival Fibroblast Cells: An In Vitro Study.

Novel nanohydrogel containing dopamine, chitosan, and extract increased cell viability and migration in human gingival fibroblast cells, showing potential as a wound healing agent in periodontal and peri-implant therapy.

Neuroscience Tridax procumbens
Jeevitha M et al (2024).
Cureus.
DOI:
10.7759/cureus.62819
PubMed:
39040712

Molecular mechanisms of Schisandra chinensis in treating depression-neuropathic pain comorbidity by network pharmacology and molecular docking analysis.

Study identified bioactive components in Schisandra chinensis for treating neuropathic pain/depressive disorder comorbidity. Components regulate pathways involving TNF, VEGF, and GH, providing insights into molecular mechanisms for potential novel therapies.

NeurosciencePain Schisandra chinensis
Mokhtari T and El-Meghawry El-Kenawy A (2024).
Neuroscience.
DOI:
10.1016/j.neuroscience.2024.07.023
PubMed:
39032805

Co-administration of sub-effective doses of the constituents of Crocus sativus L. crocins with those of the antipsychotics clozapine and risperidone counteract memory deficits caused by blockade of the NMDA receptor in rats.

Crocins, from Crocus sativus L., with clozapine or risperidone, counteract cognitive deficits induced by NMDA receptor antagonists in rats. Crocins show potential as adjunctive therapy for schizophrenia.

Neuroscience Crocus sativus
Vartzoka F et al (2024).
Phytother Res.
DOI:
10.1002/ptr.8266
PubMed:
39031890

The effect of crocin on movement disorders and oxidative DNA damage in Parkinson's disease: Insights from a randomized controlled trial.

Researchers investigated the potential of crocin, a compound from saffron, to protect against Parkinson's disease. This could lead to new treatments for the neurodegenerative disorder.

GeneticsNeuroscience Crocus sativus
Mohammad Soleymani S et al (2024).
Parkinsonism Relat Disord.
DOI:
10.1016/j.parkreldis.2024.107051
PubMed:
39025034

Polysaccharides extracted from common buckwheat (Fagopyrum esculentum) attenuate cognitive impairment via suppressing RAGE/p38/NF-κB signaling and dysbiosis in AlCl(3)-treated rats.

Study investigated the preventive effects of buckwheat polysaccharides on Alzheimer's disease in rats. FEP improved memory, reduced inflammation, and increased antioxidant activity. Results suggest potential therapeutic benefits for AD patients.

ImmunologyNeuroscience Fagopyrum esculentum
Liu YC et al (2024).
Int J Biol Macromol.
DOI:
10.1016/j.ijbiomac.2024.133898
PubMed:
39019369
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