Box-Behnken Design-Based Optimization of Phytochemical Extraction from Diplazium esculentum (Retz.) Sw. Associated with Its Antioxidant and Anti-Alzheimer's Properties.

Researchers optimized extraction of a fern extract for Alzheimer's disease treatment. It showed high BACE-1 inhibition, antioxidant properties, and synergy with AD drug, improving brain function in a fly model. The extract contains beneficial phytochemicals.

Kongsung S et al (2024).

Molecules.

DOI:

10.3390/molecules29102204

PubMed:

38792065

Effects of Piper aduncum (Piperales: Piperaceae) Essential Oil and Its Main Component Dillapiole on Detoxifying Enzymes and Acetylcholinesterase Activity of Amblyomma sculptum (Acari: Ixodidae).

Study on acaricidal activity of essential oil and Dillapiole against tick larvae. Dillapiole more effective than EO. Increased enzyme activity in treated larvae. Potential natural acaricide development.

Pereira Filho AA et al (2024).

Int J Mol Sci.

DOI:

10.3390/ijms25105420

PubMed:

38791458

Essential Oil Constituents as Anti-Inflammatory and Neuroprotective Agents: An Insight through Microglia Modulation.

This study explores how essential oils can regulate microglial function to potentially mitigate neuroinflammation and neurodegeneration. They suggest that certain components of essential oils may target specific signaling pathways involved in inflammation, offering a potential therapeutic approach for treating neurodegenerative diseases.

Stojanović NM et al (2024).

Int J Mol Sci.

DOI:

10.3390/ijms25105168

PubMed:

38791205

Caffeoylquinic Acid Mitigates Neuronal Loss and Cognitive Decline in 5XFAD Mice Without Reducing the Amyloid-β Plaque Burden.

CQA found in coffee and Centella asiatica improves cognitive function in AD model mice. Study suggests potential benefits for reducing neuroinflammation, neuronal loss, and Aβ plaque burden.

Suganuma T et al (2024).

J Alzheimers Dis.

DOI:

10.3233/JAD-240033

PubMed:

38788074

Implications of Jatropha curcas L. cake feed on swine health: A microbiota-gut-brain axis perspective.

Low phorbol ester Jatropha cake induced toxicity in pigs, impacting health and microbiota-gut-brain axis. Detoxification needed before use in feed. Relevant for animal feed safety and public health.

Zhang Z et al (2024).

Anim Sci J.

DOI:

10.1111/asj.13953

PubMed:

38783533

Discovery and verification of antidepressant active ingredients of raw and vinegar-processed Bupleurum marginatum var. Stenophyllum based on plant metabolomics and serum pharmacology.

Scientists studied Bupleurum marginatum var. stenophyllum root for its antidepressant properties. Vinegar processing enhanced the effect by increasing certain components. This research lays the groundwork for future antidepressant treatments.

Qu Z et al (2024).

J Pharm Biomed Anal.

DOI:

10.1016/j.jpba.2024.116239

PubMed:

38777665

Molecular mechanism of Chang Shen Hua volatile oil modulating brain cAMP-PKA-CREB pathway to improve depression-like behavior in rats.

Researchers combined essential oils from Acorus tatarinowii and Panax ginseng with Albizia julibrissin flower oil to create a new treatment called CSHVO for depression. CSHVO's effects and mechanisms are still unknown.

Zhang S et al (2024).

Phytomedicine.

DOI:

10.1016/j.phymed.2024.155729

PubMed:

38772184

Dopamine Dysregulation Syndrome Presenting as Overuse of Mucuna pruriens Levodopa Supplement.

Sohutskay DO et al (2024).

J Mov Disord.

DOI:

10.14802/jmd.24067

PubMed:

38768952