Danshensu from Danshen herb decreases neuronal excitability in mouse brainstem by enhancing voltage-gated K+ currents, supporting its neuroprotective effects. Dose-dependent response with potential therapeutic applications.
Danshen injection (DI) treats cardiovascular and brain diseases, improves neurological scores and reduces inflammation and oxidative stress. DI targets HIF-1α to suppress neuroinflammation and reduce ischemia/reperfusion injury.
Compounds from Arnebia guttata bind toxic metals, potentially impacting diabetes pathogenesis. Understanding metal binding may aid in diabetes treatment and management.
HSYA and Quer from a plant protect the blood-brain barrier in stroke, improving outcomes and reducing neural damage. They target specific proteins for potential treatment benefits.
Essential oils from Nepeta Cataria induce anesthesia in fish. Concentrations of 125-150µL-1 safe for short-term use, with reversible effects on posture reflex. Electrocardiographic changes observed at higher concentrations.
Scientists propose Mucuna pruriens as a cost-effective alternative to levodopa for Parkinson's disease treatment in low-income countries. More research needed on safety and efficacy before widespread use. Ensure proper cultivation and storage for clinical trials.
Alkaloids from Uncaria rhynchophylla show promise in treating Parkinson's disease by reducing inflammation and oxidative stress. Understanding their mechanism could lead to new therapies.
Researchers isolated novel compounds from Bletilla striata tubers and found two that inhibit neuroinflammation by targeting the AKT/IκB/NF-κB pathway and PTP1B overexpression. Potential for treating neuroinflammatory diseases.