Neuroscience Studies

Combination of tenuigenin-based Polygala tenuifolia willd. root extract and forsythoside a improved Alzheimer's disease.

Tenuigenin and forsythoside A extracts from specific plants show neuro-protective effects individually. When combined in a 2:1 ratio, they synergistically protect against Alzheimer's disease symptoms in cell models. Shows potential for future treatment development.

Liang G et al (2024).
Nat Prod Res.
PubMed:
38529756

Neuromodulatory effects induced by the association of Moringa oleifera Lam., Tribulus terrestris L., Undaria pinnatidifida extracts in the hypothalamus.

Study on herbal formulation with Rhodiola, Tribulus, Undaria & Moringa shows reduced serotonin & dopamine turnover, increased GnRH gene expression, and potential stress relief & libido enhancement. Promising for combating stress and fatigue.

Chiavaroli A et al (2024).
Chem Biodivers.
PubMed:
38527165

Plant Soup Formulations Show Cholinesterase Inhibition Potential in the Prevention of Alzheimer's Disease.

Researchers created vegan soups with potential Alzheimer's prevention properties by incorporating cholinesterase inhibitors. Important for understanding and potentially treating AD.

Gajowniczek-Ałasa D, Szwajgier D and Baranowska-Wójcik E (2024).
Curr Alzheimer Res.
PubMed:
38523524

The effects of Nardosinone on levodopa intervention in the treatment of Parkinson's disease.

Nardostachys jatamansi DC. roots & rhizomes treat Parkinson's disease; Nardosinone, main active component, shows potential for PD treatment. Important for PD research & treatment development.

Liu M et al (2024).
Biomed Pharmacother.
PubMed:
38522241

Protective effect of ginsenoside Rb1 against aconitine cardiotoxicity studied by myocardial injury, action potential, and calcium signaling.

Ginsenoside Rb1 can mitigate aconitine-induced cardiotoxicity by reducing myocardial damage and restoring action potential and calcium signaling balance. This study shows potential for using Rb1 as a detoxifying agent in traditional Chinese medicine.

Zhang C et al (2024).
Toxicon.
PubMed:
38519012

Integrating network pharmacology with molecular docking to rationalize the ethnomedicinal use of Alchornea laxiflora (Benth.) Pax & K. Hoffm. for efficient treatment of depression.

The study identified bioactive compounds in Alchornea laxiflora with potential antidepressant effects through molecular docking and network pharmacology. Key targets include SRC, EGFR, PIK3R1, AKT1, and MAPK1, suggesting a role in treating depression via PI3K-Akt and MAPK signaling pathways.

Jain NK et al (2024).
Front Pharmacol.
PubMed:
38505421

Correction to "Mating strategies of Vitex negundo L. var. heterophylla (Franch.) Rehder (Lamiaceae): A mixed mating system with inbreeding depression".

Scientists studied the effects of climate change on butterflies' host plants. They found that increased CO2 levels could lead to decreased plant quality, affecting butterfly populations. Important for understanding how climate change impacts ecosystems.

(2024).
Ecol Evol.
PubMed:
38500860

Cytisine-N-methylene-(5,7,4(')-trihydroxy)- isoflavone ameliorates ischemic stroke-induced brain injury in mouse by regulating the oxidative stress and BDNF-Trkb/Akt pathway.

LY01, from Sophora alopecuroides L, shows neuroprotection and potential for ischemic stroke treatment. Further research needed for mechanism and efficacy.

Li Y, Fan F and Liu Q (2024).
Eur J Pharmacol.
PubMed:
38493912