Neuroscience Studies

Glutamate application maintains quality and antioxidant capacity of fresh-cut carrots by modulating GABA shunt, phenylpropanoid and ROS metabolism.

Glutamate treatment improved flavor, GABA content, phenolic compounds, and antioxidant capacity in fresh-cut carrots. Beneficial for maintaining nutritional quality and color.

Zhang J et al (2024).
Food Chem.
PubMed:
38306904

A network pharmacology method explores the molecular mechanism of Coptis chinensis for the treatment of Alzheimer's disease.

Network pharmacology predicted molecular mechanisms of Coptis chinensis in Alzheimer's treatment, revealing active ingredients, targets, and a drug-component-disease-target network. Main signaling pathways involved PI3K-Akt, AGE-RAGE, MAPK, HIF-1, TNF, and relaxin. Berberine demonstrated strong affinity, informing future clinical research.

Qian Q and Luo WL (2024).
Medicine (Baltimore).
PubMed:
38306514

Neuroprotective Effects of Isolated Mangiferin from Swertia chirayita Leaves Regulating Oxidative Pathway on Streptozotocin-Induced Diabetic Neuropathy in Experimental Rats.

Researchers investigated the potential of Swertia chirayita, a plant with anti-inflammatory and antioxidant properties, to help with diabetic peripheral neuropathy (DPN), a complication of diabetes. Assessing oxidative stress's role in DPN is important for understanding and treating the condition.

Shivam and Gupta AK (2024).
Cent Nerv Syst Agents Med Chem.
PubMed:
38305392

Neuropharmacological insights into Gardenia jasminoides Ellis: Harnessing therapeutic potential for central nervous system disorders.

Gardenia jasminoides Ellis (GJE) is a plant used in traditional medicine in China. Recent studies show it is effective for treating Alzheimer's, Parkinson's, and major depressive disorder. However, more research is needed.

Hou Z et al (2024).
Phytomedicine.
PubMed:
38301302

Synergistic effects and molecular mechanisms of DL-3-n-butylphthalide combined with dual antiplatelet therapy in acute ischemic stroke.

Combining DL-3-n-butylphthalide (NBP) and dual antiplatelet therapy (DAPT) improves acute ischemic stroke in rats. It reduces neurological deficits, infarct area, and inflammation by suppressing the pyroptosis-inflammation pathway in brain tissues, especially in microglial cells.

Du Y et al (2024).
Int Immunopharmacol.
PubMed:
38295546

Effect of berberine on cognitive function and β-amyloid precursor protein in Alzheimer's disease models: a systematic review and meta-analysis.

Study evaluates the effects of berberine on Alzheimer's disease. Results show that it improves cognitive function and reduces the expression of amyloid precursor protein, suggesting potential neuroprotective effects. (40 words, 232 characters)

Liu JY et al (2024).
Front Pharmacol.
PubMed:
38293672

Effectiveness of Shugan Jieyu capsules for psychiatric symptoms of epilepsy: a systematic review and meta-analysis.

This study investigated the effectiveness and safety of Shugan Jieyu capsules in treating depression in epilepsy patients. Currently, there are no guidelines for depression treatment in epilepsy patients. It is important because antidepressants may worsen seizures.

Kim S, Kim Y and Cho SH (2024).
BMC Complement Med Ther.
PubMed:
38287355