Neuroscience Studies

Amelioration of age-related cognitive decline and anxiety in mice by Centella asiatica extract varies by sex, dose and mode of administration.

Scientists studied the effects of a water extract from an Ayurvedic plant on cognitive deficits, anxiety, and depression in aged mice. The extract improved cognition and reduced anxiety when administered in drinking water, while the effects were less significant when given in the diet.

Gray NE et al (2024).
bioRxiv.
PubMed:
38328129

Effect of Honokiol on culture time and survival of Alzheimer's disease iPSC-derived neurons.

Study tested honokiol on iPSC-derived neurons from an Alzheimer's patient to improve survival and culture time. Shows potential for therapeutic strategies in Alzheimer's disease research.

Le DTT et al (2024).
Bioimpacts.
PubMed:
38327632

Integration of metabolomics and transcriptomics reveals that Da Chuanxiong Formula improves vascular cognitive impairment via ACSL4/GPX4 mediated ferroptosis.

The researchers studied a traditional herbal formula called Da Chuanxiong (DCX) that improves blood circulation and protects the brain, potentially beneficial for treating Vascular Cognitive Impairment (VCI).

Lou T et al (2024).
J Ethnopharmacol.
PubMed:
38325668

In vitro and Ex vivo study targeting the development of a Lavandula stoechas L. (Ustukhuddūs) loaded Unani Transdermal patch: Implication of Unani Medicine in the treatment of Nisyan (Dementia).

The study developed and evaluated transdermal patches loaded with hydro-alcoholic extract and essential oil of L. for dementia treatment. The patches showed good physicochemical properties, sustained drug release, and non-Fickian release mechanisms. They could improve patient compliance in Unani medicine.

Fathima A F et al (2024).
Heliyon.
PubMed:
38322847

Dendrobine: A neuroprotective Sesquiterpenic Alkaloid for the Prevention and Treatment of Diseases: A Review.

Dendrobine, a compound extracted from Dendrobium nobile Lindl, has neuroprotective effects and potential in treating cognitive disorders, anxiety, depression, Alzheimer's disease, Parkinson's disease, and inflammation. It activates neuro synapses and neurotransmission pathways.

Bhardwaj K et al (2024).
Mini Rev Med Chem.
PubMed:
38321903

Origanum majorana L. polyphenols: in vivo antiepileptic effect, in silico evaluation of their bioavailability, and interaction with the NMDA receptor.

This study examined the bioavailability and antiepileptic activity of a plant extract from L. leaves. The extract showed good antiepileptic activity by delaying seizures, possibly due to the interaction of its compounds with the NMDA receptor.

Amaghnouje A et al (2024).
Front Chem.
PubMed:
38313221

Therapeutic potential of the medicinal mushroom Ganoderma lucidum against Alzheimer's disease.

Ganoderma lucidum, a medicinal mushroom, shows potential as an adjuvant for Alzheimer's disease (AD) treatment. It can delay AD progression, improve cognitive function, and inhibit various mechanisms involved in AD pathology. More research and clinical trials are needed to fully understand its therapeutic potential.

Chen XJ et al (2024).
Biomed Pharmacother.
PubMed:
38310653

Variation of the essential oil components of Citrus aurantium leaves upon using different distillation techniques and evaluation of their antioxidant, antidiabetic, and neuroprotective effect against Alzheimer's disease.

Bitter orange leaves were extracted using different methods to compare their chemical composition. The essential oils showed antioxidant and antidiabetic activities, making them potential sources for future drugs.

Elhawary EA et al (2024).
BMC Complement Med Ther.
PubMed:
38308284