Celastrol-chitosan conjugate Cel-CS1K showed promise as an antiobesity drug with higher drug loading, good solubility, and reduced toxicity compared to free Cel. It effectively reduced body weight, improved metabolic markers, and regulated adipose-related genes in obese mice, offering a potential therapeutic strategy for obese humans.
TCM herbal formula targets visceral fat, hormone imbalance, and inflammation to combat obesity. Promising alternative to conventional treatments with potential for radical effects and fewer side effects.
Researchers studied how baicalin, a compound in Radix scutellariae, can help reduce inflammation in metabolic disorders like obesity. Baicalin can potentially improve insulin resistance in obesity by modulating macrophages.
Sugar beet pulp extract (SBP-E) from ferulic acid reduces oxidative stress, improves glucose and lipid metabolism, and decreases inflammation in obesity-induced type 2 diabetes. SBP-E activates SIRT1/AMPK signaling and modulates the AMPK/SREBP1/ACC1 pathway, offering potential treatment benefits.
Chicory extract (CG) delayed weight gain, improved metabolism, reduced oxidative stress, and balanced gut microbiota in obese mice. CG may be beneficial for treating obesity and metabolic issues by targeting the gut microbiome and bile acid production.
Study uncovers therapeutic potential of gut microbiota and plant compounds for metabolic disorders. Key genes and bioactive compounds identified could lead to novel treatments for type 2 diabetes, NAFLD, obesity, and hypertension.
Researchers examined the potential of nopal cactus extracts for treating metabolic disorders like obesity. While promising in preclinical studies, more research is needed to understand their mechanisms and effectiveness in clinical settings.
Study showed that diets enriched with fennel and coriander reduced obesity risks and improved fertility in obese female rats better than chia seeds and hibiscus. Consider plant-based diets for obesity prevention.