Obesity Studies

Phyllanthus emblica Fruit Improves Obesity by Reducing Appetite and Enhancing Mucosal Homeostasis via the Gut Microbiota-Brain-Liver Axis in HFD-Induced Leptin-Resistant Rats.

Researchers found that a water extract of L. fruit effectively reduced leptin resistance in high-fat diet fed rats by improving gut barrier function, appetite regulation, and lipid metabolism. This may help in managing obesity and related complications.

Chang HY et al (2024).
J Agric Food Chem.
PubMed:
38659208

Elucidating the anti-obesity potential of bioactive fractions of kalanchoe pinnata (lam.) leaves extract using a combination of in vitro, in vivo and in silico methods along with characterisation of lead compounds through an HPTLC ms-MS(n) analytical study.

Scientists isolated and tested anti-obesity fractions from leaves. Fraction F2 showed the most potential, reducing body weight and lipids in obese mice. It contains compounds with binding capability for proteins, suggesting a therapeutic strategy for obesity.

Pratap Singh R and Pattnaik AK (2024).
Nat Prod Res.
PubMed:
38656916

A sustainable approach to prepare green synthesis of copper nanoparticles of Bauhinia variegata & Saussurea lappa: Unveiling in-vitro anti-obesity applications.

Flower extracts were used to synthesize copper nanoparticles with potential applications in stabilizing compounds, antimicrobial activity, and anti-obesity/anti-diabetic effects. This study demonstrates the versatility and benefits of using plant-synthesized nanoparticles in various fields.

Kumar M et al (2024).
Heliyon.
PubMed:
38644870

Identification of phenolic compounds from fermented Moringa oleifera Lam. leaf supplemented with Fuzhuan brick tea and their volatile composition and anti-obesity activity.

Moringa leaf added to tea, improves polyphenol content, flavor. MFP inhibits fat accumulation, improves metabolic health in mice. Promising functional food for obesity prevention.

Li X et al (2024).
J Food Sci.
PubMed:
38634238

Ethyl acetate fraction of oregano seed protects non-alcoholic fatty liver in high-fat diet-induced obese mice through modulation of Srebp-1c.

"Oregano seed extract reduces fatty liver in obese mice by regulating lipid metabolism genes. Shows potential for treating obesity and liver disease. Important for understanding natural remedies for metabolic disorders."

Lee HJ et al (2024).
Food Sci Nutr.
PubMed:
38628197

Effectiveness and care continuity in an app-based, glucagon-like peptide-1 receptor agonist-supported weight-loss service for women with overweight and obesity in the UK: A real-world retrospective cohort analysis.

Talay L and Vickers M (2024).
Diabetes Obes Metab.
PubMed:
38623616

Celastrol alleviates airway hyperresponsiveness and inflammation in obese asthma through mediation of alveolar macrophage polarization.

Celastrol from Tripterygium wilfordii roots reduces airway inflammation and hyperresponsiveness in obese asthma by balancing M1/M2 alveolar macrophage polarization, possibly through the PI3K/AKT pathway. This could lead to new therapeutic options for obese asthma.

Liang Y et al (2024).
Eur J Pharmacol.
PubMed:
38604543

Madecassoside modulates lipid metabolism in visceral adipocytes: exploring the browning, lipolysis, and lipogenesis mechanisms for potential obesity treatment.

Madecassoside from Centella asiatica has antioxidant and anti-inflammatory properties in disease models. Its effects on white adipocytes and gene knockdown mechanisms need further study.

Cho W et al (2024).
J Pharm Pharmacol.
PubMed:
38588466