Clerodane diterpenoids with in-vitro anti-neuroinflammatory activity from the tuberous root of Tinospora sagittata (Menispermaceae).

Researchers have isolated 26 diterpenoids from a Chinese medicinal plant. One compound is a new type of diterpenoid with a unique ring structure. Three compounds show promising anti-inflammatory activity, potentially useful for treating conditions involving excessive inflammation.

Song JQ et al (2023).

Phytochemistry.

DOI:

10.1016/j.phytochem.2023.113932

PubMed:

38056516

Integrated metabolomics and network pharmacology revealed the key active ingredients for the treatment of ulcerative colitis in the Citrus reticulata 'Dahongpao' peel.

Li X et al (2024).

J Pharm Biomed Anal.

DOI:

10.1016/j.jpba.2023.115887

PubMed:

38056284

Mechanisms for the biological activity of Gastrodia elata Blume and its constituents: A comprehensive review on sedative-hypnotic, and antidepressant properties.

Researchers studied Gastrodia elata Blume (a Chinese herbal medicine) and its effects on insomnia and depressive symptoms. It was found to have sedative-hypnotic and antidepressant effects, suggesting it could be a potential treatment option with fewer side effects.

Zhou HB et al (2023).

Phytomedicine.

DOI:

10.1016/j.phymed.2023.155251

PubMed:

38056151

Tannins in Phyllanthus emblica L. improves cisplatin efficacy in lung cancer cells by boosting endoplasmic reticulum stress to trigger immunogenic cell death.

Tannins in Phyllanthus emblica L. (PTF) can inhibit tumor growth and have cytotoxic effects on lung cancer cells in vitro. This suggests PTF may be a potential immunotherapy for lung cancer treatment.

Hu Q et al (2023).

Phytomedicine.

DOI:

10.1016/j.phymed.2023.155219

PubMed:

38056150

Ethanol extract of Verbena officinalis alleviates MCAO-induced ischaemic stroke by inhibiting IL17A pathway-regulated neuroinflammation.

Researchers investigated the therapeutic potential of Verbena officinalis in managing ischaemic stroke. Significant neuroprotective effects were observed, but further research is needed to understand the bioactive compounds and mechanisms involved. This study may offer insights for developing new treatment strategies.

Zhang W et al (2023).

Phytomedicine.

DOI:

10.1016/j.phymed.2023.155237

PubMed:

38056148

Alkaline lignins from Morinda citrifolia leaves are potential immunomodulatory, antitumor, and antimicrobial agents.

This study investigated the immunomodulatory, antitumor, and antimicrobial activities of lignin from Morinda citrifolia leaves. The results suggest that this lignin can activate immune cells, produce anti-inflammatory factors, and inhibit tumor and microbial growth. It has potential for developing biomedical and pharmaceutical products.

Cruz Filho IJ et al (2023).

An Acad Bras Cienc.

DOI:

10.1590/0001-3765202320221026

PubMed:

38055562

Spatial Distribution and Characterization of the Small-Molecule Metabolites and In Situ Hydrolyzed Oligosaccharides in the Rhizome of Glycyrrhiza uralensis by Desorption Electrospray Ionization-Mass Spectrometry Imaging and High-Resolution Liquid Chromatography-Mass Spectrometry.

Zhao Y et al (2023).

J Agric Food Chem.

DOI:

10.1021/acs.jafc.3c04996

PubMed:

38055271

Evaluation of Physical Properties of Denture Base Resins Containing Silver Nanoparticles of Aloe barbadensis Miller, Morinda citrifolia, and Boesenbergia rotunda and Its Anti-microbial Effect: An In Vitro Study.

Adding plant extract silver nanoparticles to PMMA denture bases increased flexural strength and hardness, with finger root extract showing the highest antimicrobial activity against Candida albicans. This suggests that AgNPs can enhance denture base properties. (40 words)

Kaul S et al (2023).

Cureus.

DOI:

10.7759/cureus.48260

PubMed:

38054116