All Studies

De novo genome assembly and annotation of the medicinal plant Tinospora cordifolia (Willd.) Miers ex Hook. f. & Thom's.

Scientists sequenced the genome of Tinospora cordifolia and identified genes responsible for the synthesis of syringin, a potential therapeutic compound. Syringin showed strong binding affinity for targets of Parkinson's and Alzheimer's diseases. This research provides valuable genomic information and insights for developing therapeutic drugs.

Genetics Tinospora cordifolia
R N et al (2023).
Funct Integr Genomics.
DOI:
10.1007/s10142-023-01262-2
PubMed:
37935874

Involvement of PI3K/AKT Pathway in the Rapid Antidepressant Effects of Crocetin in Mice with Depression-Like Phenotypes.

This study found that crocetin, an active ingredient in saffron, has a rapid antidepressant effect. It reduced depressive-like behaviors, neuroinflammation, and nerve injuries in mice by suppressing inflammatory cytokines and apoptosis through the PI3K/AKT signaling pathways. The effect lasted for at least 2 days after a single treatment.

Neuroscience Crocus sativus
Lin S et al (2023).
Neurochem Res.
DOI:
10.1007/s11064-023-04051-2
PubMed:
37935859

Eco-corona formation diminishes the cytogenotoxicity of graphene oxide on Allium cepa: Role of soil extracted-extracellular polymeric substances in combating oxidative stress.

Scientists studied the toxicity of graphene oxide (GO) on Allium cepa root tip cells and the role of extracellular polymeric substances (EPS). Pristine GO caused genotoxic effects through oxidative stress, but EPS-corona on GO reduced toxicity by reducing oxidative stress within cells.

Immunology Allium cepa
Christudoss AC, Dimkpa CO and Mukherjee A (2023).
Plant Physiol Biochem.
DOI:
10.1016/j.plaphy.2023.108123
PubMed:
37935068

Radioprotective effect of Ginkgolide B on brain: The mediating role of DCC/MST1 signaling.

Ginkgolide B (GB) from ginkgo biloba leaves shows potential protective effects on radiation-induced brain injury (RBI) by regulating the Hippo signaling pathway, suggesting its value for mitigating neurological complications and developing treatments.

Neuroscience Ginkgo biloba
Yang T, Du X and Xu L (2023).
Int J Radiat Biol.
DOI:
10.1080/09553002.2023.2281515
PubMed:
37934907

Maackiain suppresses the development of cervical cancer via AMPK priming autophagy.

Maackiain (Mac), a compound from Sophora flavescens, shows potential for treating cervical cancer due to its neuroprotective, anti-allergic, anti-inflammatory, and pro-apoptotic properties. Further research is needed to confirm its therapeutic benefits.

Cancer Sophora flavescens
He J et al (2023).
J Pharm Pharmacol.
DOI:
10.1093/jpp/rgad100
PubMed:
37934902
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