All Studies

Modulation of Immunological, Biochemical, and Histopathological Changes of Airway Remodeling by Withania somnifera in an Experimental Model of Allergic Asthma in Rats.

Researchers studied the effects of WS root extract on airway remodeling in a rat model of asthma. The extract showed potential in reducing structural changes and improving airflow limitation, offering new therapeutic options for asthma treatment.

Ali NH et al (2023).
J Pharmacopuncture.
PubMed:
37405114

The signaling pathways of traditional Chinese medicine in treating diabetic retinopathy.

Traditional Chinese medicine (TCM) shows promise for treating diabetic retinopathy (DR) by targeting inflammation, angiogenesis, and oxidative stress pathways. TCM components like curcumolide, quercetin, blueberry anthocyanins, and more have potential for DR treatment, aiding in the development of new drugs. (35 words)

Li W et al (2023).
Front Pharmacol.
PubMed:
37405050

Liquid chromatography-tandem mass spectrometry analysis of a ratio-optimized drug pair of Sophora flavescens Aiton and Coptis chinensis Franch and study on the mechanism of anti-colorectal cancer effect of two alkaloids thereof.

The drug combination of Aiton (Kushen) and Franch. (Huanglian) is used to treat laxation. This study focused on their potential anti-cancer effects against colorectal cancer. The research found that a 1:1 ratio of Kushen and Huanglian had the best anti-cancer effect. The active components, matrine and berberine, were evaluated and found to reduce the growth of colorectal cancer in mice. Additionally, the combination of matrine and berberine showed better efficacy than using them alone. The study also identified and quantified the chemical constituents of the drug pair. The findings suggest that the combination of matrine and berberine could inhibit colorectal cancer by improving intestinal microbiota and regulating a signaling pathway.

Chen Z et al (2023).
Front Oncol.
PubMed:
37404762

18β-Glycyrrhetinic Acid Alleviates P. multocida-Induced Vascular Endothelial Inflammation by PARP1-Mediated NF-κB and HMGB1 Signalling Suppression in PIEC Cells.

Lu Q et al (2023).
Infect Drug Resist.
PubMed:
37404255