All Studies

In-silico and in-vitro assessments of some fabaceae, rhamnaceae, apocynaceae, and anacardiaceae species against Mycobacterium tuberculosis H37Rv and triple-negative breast cancer cells.

Medicinal plants in South Africa's Limpopo province have long been used to treat diseases like tuberculosis and cancer. In this study, researchers evaluated the antimycobacterial and cytotoxic activity of five plants, including Rauvolfia caffra and Schinus molle, against various strains of bacteria and breast cancer cells. The extracts from R. caffra and S. molle showed promising results, particularly against M. tuberculosis. Further analysis identified a compound called norajmaline as a potential lead for antimycobacterial treatment. Additionally, the extracts from Senna petersiana, Ziziphus mucronate, R. caffra, and S. molle demonstrated potential for treating triple-negative breast cancer. Further research is needed to validate these findings and explore chemical modifications for enhanced effectiveness.

Nyambo K et al (2023).
BMC Complement Med Ther.
PubMed:
37393246

Integration of metabolomics and network pharmacology to reveal the protective mechanism underlying Wogonoside in acute myocardial ischemia rats.

Scientists investigated the protective effects of Wogonoside (Wog) from Scutellaria baicalensis Georgi (SBG) on acute myocardial ischemia (AMI). Understanding these mechanisms could lead to potential treatments for cardiovascular diseases.

Feng W et al (2023).
J Ethnopharmacol.
PubMed:
37393028