Cancer Studies

Could cannabinoids provide a new hope for ovarian cancer patients?

Researchers have found that cannabinoids, compounds derived from the Cannabis sativa plant, have anti-cancer effects and could be potential treatments for gynecological cancers. Non-psychoactive cannabinoids show promise in treating ovarian cancer, but more research is needed.

Kaur R and Javid FA (2023).
Pharmacol Res Perspect.
PubMed:
37526235

In silico studies on the phytochemical components of Lagenaria siceraria targeting aromatase receptors against breast cancer.

This study investigated the potential use of natural compounds against breast cancer. Five substances showed higher binding affinity than a commonly used treatment, Tamoxifen.

Samajdar S and Mondal P (2023).
In Silico Pharmacol.
PubMed:
37525849

MAT as a promising therapeutic strategy against triple-negative breast cancer via inhibiting PI3K/AKT pathway.

Matrine (MAT), extracted from Sophora flavescens, inhibits TNBC cell proliferation and invasion, induces apoptosis and autophagy, and inhibits the PI3K/AKT signaling pathway. Promising for TNBC treatment.

Wei S et al (2023).
Sci Rep.
PubMed:
37524857

Synthesis, antioxidant, antiproliferative activity, molecular docking and DFT studies of novel isoxazole derivatives of diosgenin, a steroidal sapogenin from Dioscorea deltoidea.

Diosgenin derivatives were synthesized and tested for antioxidant and anticancer activity against breast cancer cell lines. Two compounds showed high efficacy, suggesting potential drug candidates.

Yatoo GN and Banday JA (2023).
Fitoterapia.
PubMed:
37524127

Anticancer, Antioxidant, and Catalytic Activities of Green Synthesized Gold Nanoparticles Using Avocado Seed Aqueous Extract.

This study found that avocado seeds, typically discarded as waste, can be used to synthesize gold nanoparticles with antioxidant, anticancer, and catalytic properties, offering potential for various applications. The nanoparticles also showed good stability and recyclability, addressing concerns around cost and reusability.

Ngungeni Y et al (2023).
ACS Omega.
PubMed:
37521675

LC-MS metabolomic evidence metabolites from Oenothera rosea L´ Hér. ex Ait with antiproliferative properties on DU145 human prostate cancer cell line.

The study found that extracts from the Oenothera genus have antiproliferative activity against prostate cancer cells. Metabolomic analysis identified 40 potential anticancer compounds. O. rosea can be used as an antiproliferative agent with low concentrations.

Márquez-Flores YK et al (2023).
Biomed Pharmacother.
PubMed:
37517287

Anticancer potential of Carica papaya Linn black seed extract against human colon cancer cell line: in vitro study.

Papaya seeds may have anti-cancer properties, potentially benefiting colorectal cancer and other types, warranting further research for therapeutic purposes.

Mahrous NS and Noseer EA (2023).
BMC Complement Med Ther.
PubMed:
37516866