Salvianolic acid A provides neuroprotective effects on cerebral ischemia-reperfusion injury in rats via PKA/CREB/c-Fos signaling pathway.

Researchers investigated the neuroprotective properties of salvianolic acid A (SAA) in cerebral ischemia-reperfusion injury (CIRI). SAA, derived from Salvia miltiorrhiza Bge., shows potential in treating brain injury, but its mechanisms of action are not fully understood.

Yang R et al (2024).

Phytomedicine.

DOI:

10.1016/j.phymed.2023.155326

PubMed:

38185068

Combination of Atractylenolide I, Atractylenolide III, and Paeoniflorin promotes angiogenesis and improves neurological recovery in a mouse model of ischemic Stroke.

Study investigated the effects of Atractylenolide I, Atractylenolide III, and Paeoniflorin on promoting angiogenesis after stroke. Findings could contribute to potential therapies for improving outcomes in stroke patients.

Li H et al (2024).

Chin Med.

DOI:

10.1186/s13020-023-00872-z

PubMed:

38178130

Triptolide promotes nerve repair after cerebral ischemia reperfusion injury by regulating the NogoA/NgR/ROCK pathway.

Triptolide, derived from traditional Chinese medicine, reduces nerve damage after brain injury by inhibiting the NogoA/NgR/ROCK pathway and enhancing synaptic function. Promising treatment option for cerebral ischemia-reperfusion injury.

Zhang H et al (2024).

Folia Neuropathol.

DOI:

10.5114/fn.2023.133065

PubMed:

38174687

Danhong formula alleviates endothelial dysfunction and reduces blood pressure in hypertension by regulating MicroRNA 24 - Phosphatidylinositol 3-Kinase-Serine/Threonine Kinase- Endothelial Nitric Oxide Synthase axis.

Researchers studied the antihypertensive effects of a Chinese medicine, Danhong Formula (DHF), to understand how it improves endothelial dysfunction and reduces high blood pressure, benefiting cardiovascular health.

Yang X et al (2023).

J Ethnopharmacol.

DOI:

10.1016/j.jep.2023.117615

PubMed:

38163560

Impact of Codonopsis decoction on cerebral blood flow and cognitive function in rats with chronic cerebral ischemia.

Researchers investigated the use of Codonopsis decoction, a traditional Chinese medicine made from the dried roots of certain species of Codonopsis, in treating chronic cerebral ischemia (CCI). CCI is associated with qi and blood deficiencies and fluid depletion. This study explores the potential benefits and medicinal properties of Codonopsis in CCI treatment.

Wang J et al (2023).

J Ethnopharmacol.

DOI:

10.1016/j.jep.2023.117585

PubMed:

38159825

Volatile oil of Angelica sinensis Radix improves cognitive function by inhibiting miR-301a-3p targeting Ppp2ca in cerebral ischemia mice.

Researchers investigated the effects of Angelica Sinensis Radix (ASR) and its volatile oil (VOASR) on cognitive impairment. ASR is a Chinese medicine used for pain relief and menstrual regulation, while VOASR showed promise in improving cognitive function. Understanding their mechanisms could aid in developing treatments for cognitive impairments.

Zhao J et al (2023).

J Ethnopharmacol.

DOI:

10.1016/j.jep.2023.117621

PubMed:

38154524

Shuxuening Injection Inhibits Apoptosis and Reduces Myocardial Ischemia-Reperfusion Injury in Rats through PI3K/AKT Pathway.

Yue TT et al (2024).

Chin J Integr Med.

DOI:

10.1007/s11655-023-3650-z

PubMed:

38153596

Marein Ameliorates Myocardial Fibrosis by Inhibiting HIF-1α and TGF-β1/Smad2/3 Signaling Pathway in Isoproterenol-stimulated Mice and TGF-β1-stimulated Cardiac Fibroblasts.

Researchers studied the role of myocardial fibrosis in heart failure. Understanding this connection is important for making informed decisions in the lab regarding the disease.

Niu G et al (2023).

Curr Pharm Des.

DOI:

10.2174/0113816128282062231218075341

PubMed:

38151839