Diabetes Studies

A graminan type fructan from Achyranthes bidentata prevents the kidney injury in diabetic mice by regulating gut microbiota.

A compound from Achyranthis bidentatae (ABPW1) protects against kidney damage and intestinal issues in diabetic mice by modulating gut microbiota and producing beneficial short chain fatty acids. Potential application for diabetic kidney disease prevention.

DiabetesGastroenterology Achyranthes bidentata
Si H et al (2024).
Carbohydr Polym.
DOI:
10.1016/j.carbpol.2024.122275
PubMed:
38823933

Untargeted metabolomics, optimization of microwave-assisted extraction using Box-Behnken design and evaluation of antioxidant, and antidiabetic activities of sugarcane bagasse.

Researchers studied fruit waste as a source of bioactive compounds. This could lead to new, affordable ways to obtain valuable materials for research and product development in the lab.

DiabetesImmunology Saccharum officinarum
Ovatlarnporn C et al (2024).
Phytochem Anal.
DOI:
10.1002/pca.3395
PubMed:
38816275

Applying Network Pharmacology and Molecular Docking in the Screening for Molecular Mechanisms of Ampalaya (Momordica charantia L.) and Banaba (Lagerstroemia speciosa L.) against Type 2 Diabetes Mellitus.

Philippines validated herbal medicines (MC) and (LS) have synergistic effects in managing Type 2 diabetes. Mechanisms of compounds in these herbs can inform treatment strategies and potentially reduce the cost of conventional medications.

Diabetes Lagerstroemia speciosaMomordica charantia
Rivera RG Jr et al (2024).
Acta Med Philipp.
DOI:
10.47895/amp.vi0.7351
PubMed:
38812760

Anti-Diabetic, Anti-Cholinesterase, and Anti-Inflammatory Potential of Plant Derived Extracts and Column Semi-Purified Fractions of Ficus benghalensis.

Study examined properties of various parts of for diabetes, memory, and inflammation. Extracts may have potential for treatment. Important for developing new therapies.

DiabetesImmunology Ficus benghalensis
Rauf A et al (2024).
Front Biosci (Landmark Ed).
DOI:
10.31083/j.fbl2905183
PubMed:
38812295

Portulaca oleracea L seed extracts counteract diabetic nephropathy through SDF-1/IL10/PPARγ-mediated tuning of keap1/Nrf2 and NF-κB transcription in Sprague Dawley rats.

Purslane seeds extracts have potent antioxidant properties that can protect against diabetic nephropathy. Maintaining glycemic control is essential in preventing DN.

DiabetesImmunology Portulaca oleracea
Aziz WM et al (2024).
Diabetol Metab Syndr.
DOI:
10.1186/s13098-024-01330-y
PubMed:
38811991

Capturing of neurotoxins causing diabetes stress and nervous breakdown in the aqueous medium by naphthazarin esters.

Compounds from Arnebia guttata bind toxic metals, potentially impacting diabetes pathogenesis. Understanding metal binding may aid in diabetes treatment and management.

DiabetesNeuroscience Arnebia guttata
Sharma N and Gulati A (2024).
Luminescence.
DOI:
10.1002/bio.4761
PubMed:
38807512

Silibinin as a major component of milk thistle seed provides promising influences against diabetes and its complications: a systematic review.

Silibinin from milk thistle improves diabetes by reducing insulin resistance, oxidative stress, and inflammation. It also protects against diabetic complications like liver damage and neuropathy. Clinical studies support its potential as a treatment, but more research is needed.

Diabetes Silybum marianum
Zare Mehrjerdi P et al (2024).
Naunyn Schmiedebergs Arch Pharmacol.
DOI:
10.1007/s00210-024-03172-x
PubMed:
38801454

Attenuation of PI3K/AKT signaling pathway by Ocimum gratissimum leaf flavonoid-rich extracts in streptozotocin-induced diabetic male rats.

Flavonoid-rich extracts from O. gratissimum improved antioxidant levels and gene expressions in diabetic rats, suggesting potential for treating diabetes. Further research on active compounds is needed.

DiabetesPhytochemistry Ocimum gratissimum
Ajiboye BO et al (2024).
Biochem Biophys Rep.
DOI:
10.1016/j.bbrep.2024.101735
PubMed:
38799115
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