Diabetes Studies

Ficus carica polysaccharide extraction via ultrasound-assisted technique: Structure characterization, antioxidant, hypoglycemic and immunomodulatory activities.

Researchers optimized ultrasound-assisted extraction to isolate FCPS, a water-soluble polysaccharide from Ficus carica fruits. FCPS showed antioxidant activity, improved insulin resistance, and activated immune response, indicating its potential as an antioxidant source and functional food.

DiabetesImmunology Ficus carica
Wang W et al (2023).
Ultrason Sonochem.
DOI:
10.1016/j.ultsonch.2023.106680
PubMed:
37956509

The Antidiabetic Activity of Combining the Aqueous Extracts of Vernonia amygdalina Leaves and Tamarindus indica Fruit Pulp in Streptozotocin-Induced Wistar Rats.

Researchers investigated the antioxidant and antidiabetic activities of a combination of and extracts. The combination showed significant reduction in diabetes-related markers and could be beneficial for diabetic patients.

Diabetes Tamarindus indicaVernonia amygdalina
Tekou FA et al (2023).
Cureus.
DOI:
10.7759/cureus.46807
PubMed:
37954696

Branched fructo-oligosaccharides from Polygonatum Cyrtonema Hua as crosslinking agents for cellulose: A novel injectable and on-demand dissolution hydrogel for diabetic wound.

The researchers developed an injectable hydrogel using fructo-oligosaccharides derived from Polygonatum Cyrtonema Hua. It showed improved wound healing in diabetic mice and has potential for clinical use.

Diabetes Polygonatum cyrtonema
Ma H et al (2023).
Int J Biol Macromol.
DOI:
10.1016/j.ijbiomac.2023.128028
PubMed:
37952806

Virtual screening, pharmacokinetics & MD simulation study of active phytoconstituents of Ficus Carica Linn. against PPAR-γ in diabetes mellitus.

This study evaluated bioactive compounds from a small tree against PPAR-γ, a target for diabetes management. Quercetin-3-o-rutinoside and other compounds showed potential as anti-diabetic agents and may act as PPAR-γ agonists.

Diabetes Ficus carica
Deshpande N S, Dwivedi PSR and Revanasiddappa BC (2023).
J Biomol Struct Dyn.
DOI:
10.1080/07391102.2023.2279286
PubMed:
37948295

Diabetic wound healing of aloe vera major phytoconstituents through TGF-β1 suppression via in-silico docking, molecular dynamic simulation and pharmacokinetic studies.

Researchers investigated the potential of aloe vera compounds in inhibiting diabetic wound healing. Through molecular docking and simulation, aloe emodin was identified as a key chemical with potential. Wet lab experiments will further validate these findings.

Diabetes Aloe vera
Roney M et al (2023).
J Biomol Struct Dyn.
DOI:
10.1080/07391102.2023.2279280
PubMed:
37942697

Mulberry leaf multi-components exert hypoglycemic effects through regulation of the PI-3K/Akt insulin signaling pathway in type 2 diabetic rats.

Mulberry leaves contain compounds that can lower blood sugar levels and have been used in traditional Chinese medicine for diabetes. However, the specific effects and mechanisms of these compounds are not well understood.

Diabetes Morus alba
Zhang Y et al (2023).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2023.117307
PubMed:
37939911

Comparative polyphenolic profiling of five ethnomedicinal plants and their applicative potential in the treatment of type 2 diabetes.

These plants have been traditionally used for preventing and treating diseases like diabetes. They may contain beneficial compounds that could be useful for developing new treatments in the lab.

DiabetesEthnobotany Agrimonia eupatoriaCichorium intybusSalviaSalvia officinalisTrifolium pratenseVinca minor
Kukavica B et al (2023).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2023.117377
PubMed:
37939910

Crocin Ameliorates Diabetic Nephropathy through Regulating Metabolism, CYP4A11/PPARγ, and TGF-β/Smad Pathways in Mice.

Crocin from Crocus sativus L. can reduce oxidative stress and inflammation in diabetic nephropathy. However, the exact mechanism of action is unclear. Important for potential treatment of DN.

Diabetes Crocus sativus
Chen W et al (2023).
Curr Drug Metab.
DOI:
10.2174/0113892002257928231031113337
PubMed:
37936469
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