Virtual screening, molecular docking, molecular dynamics, and MM-GBSA approaches identify prospective fructose-1,6-bisphosphatase inhibitors from pineapple for diabetes management.

Scientists discovered a potential antidiabetic compound in pineapple waste that inhibits the enzyme FBPase. More research is needed for efficacy and safety evaluation.

Hossain MS et al (2023).

J Biomol Struct Dyn.

DOI:

10.1080/07391102.2023.2276889

PubMed:

37916669

Schisandrin A Alleviates Spatial Learning and Memory Impairment in Diabetic Rats by Inhibiting Inflammatory Response and Through Modulation of the PI3K/AKT Pathway.

Guo X et al (2024).

Mol Neurobiol.

DOI:

10.1007/s12035-023-03725-w

PubMed:

37910285

Effectiveness of cinnamon in the reduction of lipid levels in people with diabetes: a randomized clinical trial.

Researchers studied the impact of cinnamon on lipid levels in individuals with diabetes. Care about the findings if you want to explore natural ways to manage lipid levels in diabetes.

Lira Neto JCG et al (2023).

Rev Gaucha Enferm.

DOI:

10.1590/1983-1447.2023.20230051.en

PubMed:

37909519

Effect of hydroalcoholic extract of Trigonella foenum-graecum leaves on wound healing in type 1 diabetic rats.

This study evaluated the effect of 500mg/kg hydroalcoholic extract of leaves on wound healing in diabetic rats. Results showed improved wound healing, better tensiometric indices, accelerated wound contraction, faster re-epithelialisation, improved neovascularisation, better modulation of fibroblasts and macrophages, and moderate collagen formation.

Salimabad F, Fathi AN and Babaei S (2023).

J Wound Care.

DOI:

10.12968/jowc.2023.32.Sup11.S24

PubMed:

37907366

Garden Cress Seed Oil Abrogates Testicular Oxidative Injury and NF-kB-Mediated Inflammation in Diabetic Mice.

This study found that a biologically active seed oil (LSO) improved testicular dysfunction in diabetic mice by increasing testosterone levels and reducing oxidative damage and inflammation. LSO may be a potential therapeutic option for male reproductive dysfunction in diabetes.

Abu-Khudir R et al (2023).

Int J Mol Sci.

DOI:

10.3390/ijms242015478

PubMed:

37895159

In Vitro Assessment of the Antidiabetic and Anti-Inflammatory Potential of Artemisia absinthium, Artemisia vulgaris and Trigonella foenum-graecum Extracts Processed Using Membrane Technologies.

This study analyzed the antidiabetic and anti-inflammatory potential of certain herbs. The extracts from showed high inhibitory activity on α-amylase and LOX, while extracts from showed increased α-amylase inhibition activity and extracts from showed pronounced LOX inhibition activity.

Neagu E et al (2023).

Molecules.

DOI:

10.3390/molecules28207156

PubMed:

37894635

Phellinus igniarius Polysaccharides Ameliorate Hyperglycemia by Modulating the Composition of the Gut Microbiota and Their Metabolites in Diabetic Mice.

Researchers found that polysaccharides improved hyperglycemia symptoms, restored gut microbiota balance, and altered metabolic pathways in mice with type 2 diabetes, suggesting potential benefits for diabetes management.

Ni Z et al (2023).

Molecules.

DOI:

10.3390/molecules28207136

PubMed:

37894615

Salvianolic acid B and tanshinone IIA synergistically improve early diabetic nephropathy through regulating PI3K/Akt/NF-κB signaling pathway.

Salviae Miltiorrhizae Radix Et Rhizoma, a traditional Chinese medicine, contains salvianolic acid B and tanshinone IIA. These components can effectively improve early diabetic nephropathy (DN). Useful for treating DN.

Xu Z et al (2024).

J Ethnopharmacol.

DOI:

10.1016/j.jep.2023.117356

PubMed:

37890803