Diabetes Studies

Syzygium cumini (L.) skeels mitigate diabetic nephropathy by regulating Nrf2 pathway and mitocyhondrial dysfunction: In vitro and in vivo studies.

SC homeopathic preparations show potential in managing diabetes by inhibiting AGE-RAGE interaction, reducing oxidative and inflammatory stress, and potentially preventing diabetic nephropathy.

Bangar NS et al (2024).
J Ethnopharmacol.
PubMed:
39127117

Antioxidant and Antidiabetic Activity of Cornus mas L. and Crataegus monogyna Fruit Extracts.

Three green extraction methods were evaluated for polyphenols and vitamin C extraction from fruit extracts, with ASE and LE showing highest yields and antioxidant and antidiabetic activities. These extracts stimulate insulin secretion and could be beneficial for metabolic disorders.

Paun G et al (2024).
Molecules.
PubMed:
39125000

Optimization of saponin extraction from the leaves of Panax notoginseng and Panax quinquefolium and evaluation of their antioxidant, antihypertensive, hypoglycemic and anti-inflammatory activities.

Scientists developed an extraction process for saponins in and plants, showing antioxidant, antihypertensive, hypoglycemic, and anti-inflammatory properties. These saponins could be used in functional foods and natural products.

Liang ZW et al (2024).
Food Chem X.
PubMed:
39113743

Serum metabolome analysis reveals medicinal fungi Phellinus igniarius ameliorated type 2 diabetes mellitus indications in rats via modulation of amino acid and carbohydrate metabolism.

Medicinal fungus P. igniarius improves blood glucose, cholesterol, and triglyceride levels in rats, possibly by affecting metabolic pathways. Potential treatment for type 2 diabetes.

Xia J et al (2024).
Biomed Chromatogr.
PubMed:
39113379

Investigation of the phytochemical profiling and antioxidant, anti-diabetic, anti-inflammatory, and MDA-MB-231 cell line antiproliferative potentials of extracts from Ephedra alata Decne.

Study on Ephedra alata Decne extracts found high antioxidant properties, phenolic and flavonoid compounds. Acetone extract showed strongest antioxidant activity, possible anti-inflammatory, anti-diabetic, and anticancer effects. Important for potential medicinal uses.

Al Jaafreh AM et al (2024).
Sci Rep.
PubMed:
39107351

Shatavarin-IV, a steroidal saponin from Asparagus racemosus, inhibits cell cycle progression and epithelial-to-mesenchymal transition in AGS cells under hyperglycemic conditions.

A study found that Shatavarin-IV, a compound from Asparagus racemosus, effectively inhibits gastric cancer progression in hyperglycemic conditions by inducing cell cycle arrest and apoptosis, inhibiting migration and invasion, and regulating ECM turnover. This could lead to new treatments for patients with GC-diabetes co-morbidity.

Chatterjee A et al (2024).
Steroids.
PubMed:
39106908

The effect of Andaliman (Zanthoxylum acanthopodium DC.) fruit extracted with ethanol on TNF-α and TRPA-1 levels in type II diabetes-induced mice.

Study looked at Andaliman fruit extract in T2DM mouse models. Found decreased TNF-α and TRPA-1 levels. May have potential for treating diabetes-related inflammation and pain.

Simbolon BM et al (2024).
J Adv Vet Anim Res.
PubMed:
39101085

Natural product-based treatment potential for type 2 diabetes mellitus and cardiovascular disease.

Researchers investigated the link between type 2 diabetes and cardiovascular disease, finding common risk factors and proposing natural supplement treatment. This could be a promising preventive and therapeutic option for both diseases.

Shrivastav D et al (2024).
World J Diabetes.
PubMed:
39099809