Diabetes Studies

Assessment of Antimicrobial Activity of Chitosan, ZnO, and Urtica dioica-ZnO NPs Against Staphylococcus aureus Isolated from Diabetic Ulcers.

Survey synthesized chitosan, ZnO, and ZnO-U. dioica nanoparticles to treat antibiotic-resistant S. aureus infections in diabetic ulcers. NPs showed high antibacterial effect and decreased virulence gene expression, making them a potential antimicrobial agent for diabetic ulcers.

AntimicrobialDiabetes Urtica dioica
Najafabadi SS et al (2024).
Curr Microbiol.
DOI:
10.1007/s00284-024-03633-9
PubMed:
39096343

Tannins-enriched fraction of TeMac™ protects against aluminum chloride induced Alzheimer's disease-like pathology by modulating aberrant insulin resistance and alleviating oxidative stress in diabetic rats.

Researchers investigated the potential of Terminalia macroptera in protecting against biochemical changes in Alzheimer's disease in diabetic rats. This plant shows promise in modulating insulin signaling and oxidative stress, offering potential therapies for Alzheimer's disease.

DiabetesImmunologyNeuroscience Terminalia macroptera
Akamba Ambamba BD et al (2024).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2024.118653
PubMed:
39094753

Electrospun Cerium Oxide Nanoparticle/Aloe Vera Extract-Loaded Nanofibrous Poly(Ethylene Oxide)/Polyurethane Mats As Diabetic Wound Dressings.

This study created aloe vera-infused nanofibrous patches and ceria nanoparticle-based nanofibrous webs with clindamycin for diabetic wound healing. It effectively inhibits bacterial growth, releases drugs sustainably, promotes wound contraction, and reduces glucose levels and inflammation. It is a promising treatment for diabetic wounds.

Diabetes Aloe vera
Ghosh A et al (2024).
ACS Appl Bio Mater.
DOI:
10.1021/acsabm.4c00475
PubMed:
39093691

Structurally Diverse Stilbenoids as Potent α-Glucosidase Inhibitors with Antidiabetic Effect from Morus alba.

Researchers isolated 15 new stilbenoids from the tree , showing potential as antidiabetic agents. Albaphenols A, C, and E exhibit unique structures and strong α-glucosidase inhibition. Mulberrofuran G displays potent antihyperglycemic activity in diabetic mice.

Diabetes Morus alba
Tian LL, Bi YX and Zhang H (2024).
J Agric Food Chem.
DOI:
10.1021/acs.jafc.4c01681
PubMed:
39092914

Assessing anticancer, antidiabetic, and antioxidant capacities in green-synthesized zinc oxide nanoparticles and solvent-based plant extracts.

Researchers studied the potential of gum arabic tree-based zinc-oxide nanoparticles (ZnO-NPs) for cancer, diabetes, and oxidative stress. ZnO-NPs showed promising results for inhibiting cancer cell growth and antioxidant activity, suggesting potential pharmacological applications. Further research on safety and pathways is needed.

CancerDiabetesImmunology Acacia nilotica
Azeem M et al (2024).
Heliyon.
DOI:
10.1016/j.heliyon.2024.e34073
PubMed:
39092244

Electrospun PCL/PVA/PHMB nanofibers incorporating Ziziphus jujuba fruit extract as promising wound dressings with potent antibacterial and antidiabetic properties.

Electrospun nanofiber wound dressings with PHMB and ZJ fruit extract showed superior antibacterial and antidiabetic effects, accelerating wound healing and reducing inflammation, making them suitable for diabetic patients. Use PCL/PVA/PHMB/ZJ for advanced wound care.

Diabetes Ziziphus jujuba
Fahimirad S et al (2024).
J Biomater Sci Polym Ed.
DOI:
10.1080/09205063.2024.2384299
PubMed:
39088278

Leonurine Ameliorates Diabetic Nephropathy through GPX4-Mediated Ferroptosis of Endothelial Cells.

Researchers studied the impact of Leonurine (LEO) on ferroptosis in diabetic nephropathy (DN). LEO, known for anti-inflammatory and anti-cancer properties, may provide new therapeutic strategies for DN.

Diabetes Leonurus japonicus
Yu X et al (2024).
Front Biosci (Landmark Ed).
DOI:
10.31083/j.fbl2907270
PubMed:
39082358

Antidiabetic effect of combined extract of Coccinia grandis and Blumea balsamifera on streptozotocin-nicotinamide induced diabetic rats.

Combining C. grandis and B. balsamifera extracts may improve antidiabetic effects, leading to lower doses and higher efficacy in treatment.

Diabetes Blumea balsamifera
Putra IMWA et al (2024).
J Ayurveda Integr Med.
DOI:
10.1016/j.jaim.2024.101021
PubMed:
39079440
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