Endocrinology Studies

Lavender and metformin effectively propagate progesterone levels in patients with polycystic ovary syndrome: A randomized, double-blind clinical trial.

Study evaluated the effects of lavender and metformin on PCOS patients. Findings can inform treatments for PCOS, a common hormonal disorder among women.

Endocrinology Lavandula angustifolia
Simaei SR et al (2023).
Fitoterapia.
DOI:
10.1016/j.fitote.2023.105720
PubMed:
37931721

Involvement of estrogen receptor activation in kaempferol-3-O-glucoside's protection against aging-related cognition impairment and microglial inflammation.

Kaempferol-3-O-glucoside (K-3-G), a flavonoid in Cuscuta Chinensis Lam., improved cognition and reduced inflammation in aging mice. It activated estrogen receptors (ERs) and inhibited microglial inflammation through ERs, suggesting it could be a therapeutic agent for cognitive decline.

EndocrinologyImmunologyNeuroscience Cuscuta chinensis
Liu H et al (2023).
Exp Cell Res.
DOI:
10.1016/j.yexcr.2023.113849
PubMed:
37926343

Comparative physiochemical and transcriptomic analysis reveals the influences of cross-pollination on ovary and fruit development in pummelo (Citrus maxima).

Cross-pollination with Guanximiyou pummelo improves the fruit shape (FS) quality of Shuijingmiyou pummelo. Physiochemical and transcriptomic differences were found between self-pollinated and cross-pollinated fruits. This study provides insight into the influence of cross-pollination on pummelo fruit development and quality improvement.

Endocrinology Citrus maxima
Wang S et al (2023).
Sci Rep.
DOI:
10.1038/s41598-023-46058-3
PubMed:
37925539

The anticancer potential of chemical constituents of Moringa oleifera targeting CDK-2 inhibition in estrogen receptor positive breast cancer using in-silico and in vitro approches.

Scientists investigated the potential of compounds in Moringa oleifera to inhibit CDK-2, a protein target in estrogen receptor-positive breast cancer. Ellagic acid, chlorogenic acid, and quercetin showed the most promise and further research is needed to validate these findings.

CancerEndocrinology Moringa oleifera
Sultan R et al (2023).
BMC Complement Med Ther.
DOI:
10.1186/s12906-023-04198-z
PubMed:
37925393

Therapeutic Effect of Tinospora cordifolia (Willd) Extracts on Letrozole-Induced Polycystic Ovarian Syndrome and its Complications in Murine Model.

The researchers investigated the safety and effectiveness of Tinospora cordifolia (TC) in treating polycystic ovarian syndrome. Understanding its benefits and potential risks can help guide decisions in the lab and improve treatment options for the syndrome.

Endocrinology Tinospora cordifolia
Rani R, Sharma AK and Chitme HR (2023).
Clin Med Insights Endocrinol Diabetes.
DOI:
10.1177/11795514231203864
PubMed:
37901891

Systematic pharmacology-based strategy to explore the mechanism of Semen Strychni for treatment of papillary thyroid carcinoma.

Network pharmacology and experimental verification were used to study the effects of Semen Strychni on papillary carcinoma thyroid (PTC). Brucine was identified as a suitable marker and showed strong anti-PTC activity, indicating Semen Strychni's potential as a treatment for PTC.

Endocrinology Strychnos nux-vomica
Mao J et al (2023).
Sci Rep.
DOI:
10.1038/s41598-023-45741-9
PubMed:
37898675

Icariin induces developmental toxicity via thyroid hormone disruption in zebrafish larvae.

Icariin, a natural compound from a Chinese herb, was found to negatively affect the development of zebrafish embryos. It disrupted thyroid development and hormone synthesis, indicating potential toxicity. Risk assessments should be done before using ICA in clinical practice.

Endocrinology Epimedium brevicornu
Wu M et al (2023).
Food Chem Toxicol.
DOI:
10.1016/j.fct.2023.114155
PubMed:
37898232

Identification of apposite antagonist for androgen receptor in prostate cancer: an in silico study of fenugreek compounds.

Fenugreek compounds were tested for their potential as anti-cancer agents on benign prostate cancer by targeting the androgen receptor. The compounds chlorogenic acid and kaempferol showed the most promise, indicating their potential for drug development in BPC treatment. (25 words)

CancerEndocrinology Trigonella foenum
Olugbogi EA et al (2023).
J Biomol Struct Dyn.
DOI:
10.1080/07391102.2023.2273988
PubMed:
37897191
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