Immunology Studies

In Vitro Antioxidant and In Vivo Antigenotoxic Features of a Series of 61 Essential Oils and Quantitative Composition-Activity Relationships Modeled through Machine Learning Algorithms.

Mladenović M et al (2023).
Antioxidants (Basel).
PubMed:
37891894

Salvianolic acid B and tanshinone IIA synergistically improve early diabetic nephropathy through regulating PI3K/Akt/NF-κB signaling pathway.

Salviae Miltiorrhizae Radix Et Rhizoma, a traditional Chinese medicine, contains salvianolic acid B and tanshinone IIA. These components can effectively improve early diabetic nephropathy (DN). Useful for treating DN.

Xu Z et al (2024).
J Ethnopharmacol.
PubMed:
37890803

Inhibition of Phagocytosis by Silibinin in Mouse Macrophages.

Silibinin, derived from milk thistle, effectively inhibits macrophage activation by preventing morphological changes and reducing phagocytosis. It targets key inflammatory pathways, making it a potential anti-inflammatory agent with promising therapeutic properties.

Sun KH, Lee MY and Jeon YJ (2023).
Curr Issues Mol Biol.
PubMed:
37886956

Preventive effects of inotodiol on polyinosinic-polycytidylic acid-induced inflammation in human dermal fibroblasts.

Inotodiol, a compound found in Chaga mushroom, has significant anti-inflammatory effects. It can suppress the inflammation induced by poly(I:C), which mimics double-strand RNA, in human dermal fibroblast cells. This suggests that inotodiol could be used as an effective anti-inflammatory agent in cosmetics.

Won GW et al (2023).
Heliyon.
PubMed:
37886743

Centella asiatica promotes antioxidant gene expression and mitochondrial oxidative respiration in experimental autoimmune encephalomyelitis.

Centella asiatica (Centella) does not improve cognitive function or reduce disease burden in multiple sclerosis (MS) in mice. However, it does increase antioxidant gene expression and mitochondrial respiratory activity, suggesting potential benefits in MS patients.

Kundu P et al (2023).
Res Sq.
PubMed:
37886497

Developmental landscape of computational techniques to explore the potential phytochemicals from Punica granatum peels for their antioxidant activity in Alzheimer's disease.

Researchers prepared and studied a library of 1,000 compounds from peels to find antioxidants for Alzheimer's disease. Using computational calculations, they identified active compounds and performed molecular docking, optimization, and toxicity evaluation. Hesperidin showed promise as a potential drug for Alzheimer's treatment.

Parveen S et al (2023).
Front Mol Biosci.
PubMed:
37886033