Dopamine-polyethyleneimine co-deposition of a capillary for α-glucosidase immobilization and its application in enzyme inhibitor screening.

Researchers established an online method based on CE to screen α-glucosidase inhibitors from traditional Tibetan medicine extracts. The method involved functionalizing the inner wall of the capillary column and immobilizing the α-glucosidase on it. Results showed good repeatability and batch-to-batch reproducibility, with 16 traditional Tibetan medicines screened out with inhibitory activity. Rheum australe showed the strongest inhibitory effect with an inhibitory rate of 83.3 ± 0.4%. The study demonstrated the effectiveness of the method in finding potential enzyme inhibitors.

Li P et al (2021).

Electrophoresis.

DOI:

10.1002/elps.202100185

PubMed:

34347304

Phytochemical Composition, Antioxidant, Antiacetylcholinesterase, and Cytotoxic Activities of Rumex crispus L.

Researchers evaluated three solvents of increasing polarity to extract phenolic compounds from the aerial part of L. plant. The methanol extract had significant anti-oxidant and anti-cholinesterase activities, while the dichloromethane extract had the highest cytotoxic activity against cancer cells. GC-MS analysis identified three new compounds, and HPLC chromatograms showed several phenolic compounds. The study suggests that L. plant extracts could be considered as natural supplements for food and pharmaceuticals due to their phenolic compounds.

Saoudi MM et al (2021).

Int J Anal Chem.

DOI:

10.1155/2021/6675436

PubMed:

34306086

Stigmasterol can be new steroidal drug for neurological disorders: Evidence of the GABAergic mechanism via receptor modulation.

Researchers explored the association between genetic variations in GABA receptor subunit genes and these disorders in a large sample. They found that some variants increase the risk of developing anxiety and epilepsy, while others are protective. This study highlights the importance of understanding the genetic basis of these disorders and could lead to the development of targeted therapies.

Karim N et al (2021).

Phytomedicine.

DOI:

10.1016/j.phymed.2021.153646

PubMed:

34280827

Mitoprotective Effects of Centella asiatica (L.) Urb.: Anti-Inflammatory and Neuroprotective Opportunities in Neurodegenerative Disease.

Scientists are exploring the potential of a medicinal plant extract from Centella asiatica (CA) as a solution for healthy aging. Past studies have shown that its key components exhibit anti-inflammatory, neuroprotective, and cognitive benefits, linked to the plant's antioxidant and mitoprotective properties. Mitochondrial dysfunction and oxidative stress play a significant role in aging and neurodegenerative diseases such as Alzheimer's and Parkinson's diseases. Researchers believe that CA could be an effective treatment for brain aging and neurodegenerative diseases based on its antioxidative and mitoprotective effects.

Wong JH, Barron AM and Abdullah JM (2021).

Front Pharmacol.

DOI:

10.3389/fphar.2021.687935

PubMed:

34267660

Phytochemical profiling of Blumea laciniata (Roxb.) DC. and its phytopharmaceutical potential against diabetic, obesity, and Alzheimer's.

Swaraz AM et al (2021).

Biomed Pharmacother.

DOI:

10.1016/j.biopha.2021.111859

PubMed:

34246953

Antidepressant effects of total iridoids of Valeriana jatamansi via the intestinal flora-blood-brain barrier pathway.

Zhang L et al (2021).

Pharm Biol.

DOI:

10.1080/13880209.2021.1944222

PubMed:

34236293

Treatment of opium addiction in persian medicine: A review study.

Opium addiction is a major public health issue in Iran, where it is the most commonly used illicit drug. This study examined treatment strategies from the perspective of Persian medicine. The search was conducted in Persian medicine books and databases using keywords related to opioids and opium since 2000 AD. Gradual and delayed reduction of opium levels, combined with appropriate spice replacements, was suggested for quitting. The study highlights the potential of traditional medicine in addressing modern public health problems.

Kamali M et al (2021).

J Educ Health Promot.

DOI:

10.4103/jehp.jehp_5_21

PubMed:

34222532

Phenolic constituents isolated from Senna tora sprouts and their neuroprotective effects against glutamate-induced oxidative stress in HT22 and R28 cells.

Senna tora sprouts were found to have increased antioxidant and neuroprotective properties compared to seeds due to their higher levels of phenolic compounds, specifically compounds 1 and 3-6. Two new naphthopyrone glycosides were isolated from the sprouts. These compounds were found to protect neuronal cells against oxidative stress. Sprouts and their constituents could potentially be developed as natural neuroprotective agents.

Kwon J et al (2021).

Bioorg Chem.

DOI:

10.1016/j.bioorg.2021.105112

PubMed:

34216894