Hepatic encephalopathy in swine experimentally poisoned with Senna occidentalis seeds: Effects on astrocytes.

Senna occidentalis, a plant that can be ingested accidentally by humans and animals, was studied in a pig model. Pigs were fed rations containing 5%, 7.5%, and 10% S. occidentalis seeds for 7-11 days. All treated pigs showed symptoms of hepatoencephalopathy, including incoordination, ataxia, and anorexia. Biochemical changes were also observed, such as increased enzyme levels and higher serum bilirubin and ammonia levels. Microscopic analysis showed acute hepatocellular swelling, necrosis in various organs, and damage to astrocytes in the brain. This pig model could be used to study poisoning by S. occidentalis and other conditions leading to hepatoencephalopathy.

Chileski GS et al (2021).

Toxicon.

DOI:

10.1016/j.toxicon.2021.08.018

PubMed:

34437876

Cnidoscolus aconitifolius-supplemented diet enhanced neurocognition, endogenous antioxidants and cholinergic system and maintains hippocampal neuronal integrity in male Wistar rats.

Researchers conducted a study on the memory-enhancing effect of a -supplemented diet using the Morris water maze and novel object recognition test. The results showed that a -enriched diet was effective in improving memory and neurobehavioral performance. The findings suggest that incorporating into the diet may be beneficial for cognitive function.

Adebayo OG et al (2021).

Drug Metab Pers Ther.

DOI:

10.1515/dmdi-2021-0138

PubMed:

34390637

Correction: Chemical compounds with a neuroprotective effect from the seeds of Celosia argentea L.

Researchers from China investigated the neuroprotective compounds found in the seeds of L. They identified several chemical compounds that displayed neuroprotective effects on cell models of Parkinson's disease. The study highlights the potential therapeutic value of these compounds in the treatment of Parkinson's disease.

Guo J et al (2021).

Food Funct.

DOI:

10.1039/d1fo90080c

PubMed:

34382990

Acteoside isolated from Colebrookea oppositifolia attenuates I/R brain injury in Wistar rats via modulation of HIF-1α, NF-κB, and VEGF pathways.

Acteoside, isolated from C. oppositifolia, was studied for its anti-stroke activity in Wistar rats. Rats were pretreated with acteoside at different doses before being subjected to ischemia-reperfusion brain injury. Neurological, motor-cognitive functions were evaluated along with morphological, biochemical, histopathological, and gene expression studies. Results showed that acteoside had a protective effect against I/R induced brain injury, making it a potential therapeutic agent for stroke treatment.

Viswanatha GL et al (2021).

Inflammopharmacology.

DOI:

10.1007/s10787-021-00851-6

PubMed:

34365555

Overview of therapeutic potentiality of Angelica sinensis for ischemic stroke.

Researchers studied the use of Angelica sinensis in treating ischemic stroke, a disease caused by blood flow interruption that damages neurons. Chinese medicine, particularly Angelica sinensis, was found to be beneficial in the treatment and recovery of ischemic stroke. The study highlights the potential benefits of using Chinese medicine in treating neurological disorders.

Han Y et al (2021).

Phytomedicine.

DOI:

10.1016/j.phymed.2021.153652

PubMed:

34362631

Phytochemical Composition, Antioxidant Activity, and Enzyme Inhibitory Activities (α-Glucosidase, Xanthine Oxidase, and Acetylcholinesterase) of Musella lasiocarpa.

Li R et al (2021).

Molecules.

DOI:

10.3390/molecules26154472

PubMed:

34361630

The Effect of Ferula communis Extract in Escherichia coli Lipopolysaccharide-Induced Neuroinflammation in Cultured Neurons and Oligodendrocytes.

Ferutinin, a compound found in the plant genus L., has properties that may benefit the treatment of neurodegenerative and demyelinating diseases. In an experimental system, human neurons and oligodendrocytes were treated with a pro-inflammatory agent and then pretreated with ferutinin. Results suggested that ferutinin may act as an antioxidant and anti-inflammatory agent. However, further studies are needed to confirm its potential use as a treatment strategy for diseases characterized by inflammation and oxidative stress.

Maiuolo J et al (2021).

Int J Mol Sci.

DOI:

10.3390/ijms22157910

PubMed:

34360675

Amomum tsaoko fruit extract exerts anticonvulsant effects through suppression of oxidative stress and neuroinflammation in a pentylenetetrazol kindling model of epilepsy in mice.

Wang K et al (2021).

Saudi J Biol Sci.

DOI:

10.1016/j.sjbs.2021.06.007

PubMed:

34354406