The neuroprotective potential of turmeric rhizome and bitter melon on aspartame-induced spatial memory impairment in rats.

Turmeric and bitter melon extracts improved memory and protected the brain in rats exposed to aspartame, suggesting their antioxidant properties could prevent memory problems caused by aspartame.

Suswidiantoro V et al (2023).

Heliyon.

DOI:

10.1016/j.heliyon.2023.e21693

PubMed:

38027700

Integrated metabolomics and network pharmacology to reveal the mechanism of areca nut addiction.

Areca nut addiction mechanisms were explored using metabolomics and network pharmacology. Arecoline and G-protein coupled receptor signaling were identified as key factors, affecting dopamine and serotonin systems. The study also revealed a potential link between bile acids and addictive behavior, providing insights for interventions and treatment.

Li M et al (2023).

Addict Biol.

DOI:

10.1111/adb.13352

PubMed:

38017647

Schisandrin B, a dual positive allosteric modulator of GABA(A) and glycine receptors, alleviates seizures in multiple mouse models.

Wu J et al (2024).

Acta Pharmacol Sin.

DOI:

10.1038/s41401-023-01195-3

PubMed:

38017298

Tomato and lemon extracts synergistically improve cognitive function by increasing brain-derived neurotrophic factor levels in aged mice.

Yoon KN et al (2024).

Br J Nutr.

DOI:

10.1017/S0007114523002301

PubMed:

38016800

Baicalin exerts neuroprotective actions by regulating the Nrf2-NLRP3 axis in toxin-induced models of Parkinson's disease.

Baicalin, a compound derived from Scutellaria baicalensis, has been found to protect against oxidative stress and inflammation in Parkinson's disease. It activates Nrf2 to increase antioxidant enzymes and suppresses NLRP3 inflammasome activation.

Huang J et al (2024).

Chem Biol Interact.

DOI:

10.1016/j.cbi.2023.110820

PubMed:

38016618

Antidepressant-like Effect of Oroxylum indicum Seed Extract in Mice Model of Unpredictable Chronic Mild Stress.

Chalermwongkul C et al (2023).

Nutrients.

DOI:

10.3390/nu15224742

PubMed:

38004136

Pectolinarigenin Improves Oxidative Stress and Apoptosis in Mouse NSC-34 Motor Neuron Cell Lines Induced by C9-ALS-Associated Proline-Arginine Dipeptide Repeat Proteins by Enhancing Mitochondrial Fusion Mediated via the SIRT3/OPA1 Axis.

PR-DPR, produced by C9-ALS, leads to motor neuron degeneration. PLG, an antioxidant from a medicinal herb, reduces ROS and apoptosis caused by PR-DPR by activating the SIRT3/OPA1 axis. PLG shows potential for C9-ALS drug development.

Fu RH et al (2023).

Antioxidants (Basel).

DOI:

10.3390/antiox12112008

PubMed:

38001861

Gardenia jasminoides J. Ellis extract attenuates memory impairment in rats with Alzheimer's disease by suppressing NLRP3 inflammasome.

Gardenia jasminoides J. Ellis extract (GJ-4) showed neuroprotective effects in a rat model of Alzheimer's disease (AD) by reducing AD-like behaviors, apoptosis, and inflammation in the hippocampus. GJ-4 has potential as a drug for treating AD.

Wang Y et al (2023).

Brain Res.

DOI:

10.1016/j.brainres.2023.148687

PubMed:

38000495