Neuroscience Studies

Polygonatum sibiricum polysaccharide regulation of gut microbiota: A viable approach to alleviate cognitive impairment.

Polygonatum sibiricum polysaccharide (PSP) improves gut health, reduces inflammation, and may alleviate cognitive impairment by modulating gut-brain axis communication. Important for understanding and treating neurological diseases.

GastroenterologyNeuroscience Polygonatum sibiricum
Jiang Y et al (2024).
Int J Biol Macromol.
DOI:
10.1016/j.ijbiomac.2024.134494
PubMed:
39111476

Centella asiatica effect on traumatic brain injury: A systematic review.

Study on herbal medicine's impact on traumatic brain injury in rat model. Potential neuropharmacology treatment for TBI. Key for improving morbidity and mortality rates globally.

Neuroscience Centella asiatica
Rosyidi RM et al (2024).
Surg Neurol Int.
DOI:
10.25259/SNI_176_2024
PubMed:
39108365

Geniposide exerts the antidepressant effect by affecting inflammation and glucose metabolism in a mouse model of depression.

Geniposide from gardenia jasminoides shows promise as an antidepressant by regulating arachidonic acid and glucose metabolism, reducing inflammation in depressed mice. This could lead to improved therapeutic options for depression.

ImmunologyNeuroscience Gardenia jasminoides
Chen G et al (2024).
Chem Biol Interact.
DOI:
10.1016/j.cbi.2024.111182
PubMed:
39098740

A refined formula derived from Jiawei-Xiaoyao pill exerts rapid antidepressant-like effects in LPS-induced depression by reducing neuroinflammation and restoring neuroplasticity signaling.

Researchers studied the Jiawei-Xiaoyao Pill for depression treatment. It acts quickly due to a synergistic effect of Gardeniae Fructus and other herbs. Identifying this refined formula is crucial for quality control of the pill.

Neuroscience Angelica sinensis
Wu Z et al (2024).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2024.118647
PubMed:
39094756

Tannins-enriched fraction of TeMac™ protects against aluminum chloride induced Alzheimer's disease-like pathology by modulating aberrant insulin resistance and alleviating oxidative stress in diabetic rats.

Researchers investigated the potential of Terminalia macroptera in protecting against biochemical changes in Alzheimer's disease in diabetic rats. This plant shows promise in modulating insulin signaling and oxidative stress, offering potential therapies for Alzheimer's disease.

DiabetesImmunologyNeuroscience Terminalia macroptera
Akamba Ambamba BD et al (2024).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2024.118653
PubMed:
39094753

PACAP/VIP in the prefrontal cortex mediates the rapid antidepressant effects of zhizichi decoction.

ZZCD, a traditional Chinese medicine, is safer and exhibits quicker antidepressant effects compared to Gardenia jasminoides alone. Its mechanism involves the activation of prefrontal PACAP/VIP.

Neuroscience Gardenia jasminoides
Ren L et al (2024).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2024.118638
PubMed:
39084272

Polysaccharide extracted from Atractylodes macrocephala improves the spleen deficiency constipation in mice by regulating the gut microbiota to affect the 5-HT synthesis.

Researchers investigated the bioactive compounds in Atractylodes macrocephala to understand its medicinal benefits for gastrointestinal issues. Identifying these compounds may lead to improved treatment options for digestive disorders.

GastroenterologyNeuroscience Atractylodes macrocephala
Chen L et al (2024).
Neurogastroenterol Motil.
DOI:
10.1111/nmo.14875
PubMed:
39077771

Neuroprotective effects of total phenolics from Hemerocallis citrina Baroni leaves through the PI3K/AKT pathway.

Baroni leaves contain compounds with potential neuroprotective effects. Studies suggest they may modulate key targets through the PI3K/AKT pathway, reducing cell damage and inflammation. This research could lead to new antidepressant drug development.

Neuroscience Hemerocallis citrina
Jia Y et al (2024).
Front Pharmacol.
DOI:
10.3389/fphar.2024.1370619
PubMed:
39070797
1 5 6 7 16 171