Diabetes Studies

Evaluation of Sechium edule fruit attenuation impact on the cardiomyopathy of the STZ-induced diabetic rats.

Chayote extract has high phenolic and flavonoid contents, reducing blood sugar and improving lipid profile in diabetic rats. It also lowers urea, creatinine, and liver enzyme levels, and improves ECG parameters. Promising for diabetes treatment, but more research needed on molecular mechanisms.

Mohammad FS et al (2024).
Heliyon.
PubMed:
38742087

Green Synthesis of Silver Nanoparticles Using Zingiber officinale and Ocimum gratissimum Formulation for Its Anti-inflammatory and Antidiabetic Activity: An In Vitro Study.

Researchers synthesized silver nanoparticles using herbal extracts from ginger and onion, showing significant anti-inflammatory and antidiabetic effects in vitro. This green synthesis method could lead to new pharmaceutical treatments for diabetes and inflammation.

Anandachockalingam A et al (2024).
Cureus.
PubMed:
38741855

Leonuride protects diabetic nephropathy by activating SREBPs pathway.

Tossers studied Leonuride from Leonurus japonicus Houttuyn on DN. It improved glucose/lipid metabolism and kidney function in diabetic mice by inhibiting SREBPs. Potential new treatment for DN.

Ma L et al (2024).
Pak J Pharm Sci.
PubMed:
38741401

HPLC-Based Metabolomic Analysis and Characterization of Amaranthus cruentus Leaf and Inflorescence Extracts for Their Antidiabetic and Antihypertensive Potential.

This study found that are rich in antioxidants and have potential antidiabetic and antihypertensive properties. The extracts showed promising results in in vitro and in vivo tests, suggesting potential use as functional food.

Araujo-León JA et al (2024).
Molecules.
PubMed:
38731493

Achyranthes bidentata polysaccharide ameliorates type 2 diabetes mellitus by gut microbiota-derived short-chain fatty acids-induced activation of the GLP-1/GLP-1R/cAMP/PKA/CREB/INS pathway.

ABP polysaccharide improves gut microbiota in T2DM mice, increasing SCFAs and GLP-1 levels, activating GLP-1/INS pathway. Potential T2DM therapeutic candidate.

Xia T et al (2024).
Int J Biol Macromol.
PubMed:
38729481

Atractylenolide-I Alleviates Hyperglycemia-Induced Heart Developmental Malformations through Direct and Indirect Modulation of the STAT3 Pathway.

Atractylenolide-I from Baizhu herb may prevent congenital heart defects in infants of mothers with gestational diabetes. Potential for new preventive and therapeutic treatments.

Wang M et al (2024).
Phytomedicine.
PubMed:
38728919

Hypoglycemic, anti-inflammatory, and neuroprotective potentials of crude methanolic extract from Acacia nilotica L. - results of an in vitro study.

Babul plant extract has potential as a natural remedy for diabetes, inflammation, and neuroprotection. It inhibits key enzymes and shows promise in reducing inflammatory markers. Further research is needed for validation.

Rauf A et al (2024).
Food Sci Nutr.
PubMed:
38726429

Silibinin as a promising treatment for diabetes: Insights into behavioral and metabolic changes in an animal model.

Silibinin from milk thistle improves insulin secretion and sensitivity, reduces hyperglycemia in diabetic rats. Also improves anxiety-like behaviors and learning, and protects liver function.

Dagli Gul AS, Boyuk Ozcan G and Arihan O (2024).
Food Sci Nutr.
PubMed:
38726421