Neuroscience Studies

Targeting key players in Alzheimer's disease: bioactive compounds from Moringa oleifera, Desmodium gangeticum, and Centella asiatica as potential therapeutics.

Researchers identified natural compounds from plants that can inhibit BACE1 enzyme, crucial in Alzheimer's development. Astilbin showed promise in altering BACE1 behavior, potentially managing Alzheimer's Disease.

Premkumar T and Sajitha Lulu S (2024).
J Biomol Struct Dyn.
PubMed:
38887054

Role of Thymoquinone on sleep restriction and its mitigating effect on leptin-mediated signaling pathway in rat brain.

Thymoquinone in Nigella sativa could help improve leptin levels and metabolism during sleep restriction by modulating brain circuits. Important for understanding how stress and sleep impact appetite regulation.

Manoharan N et al (2024).
Mol Biol Rep.
PubMed:
38886257

Gastrodin relieves Parkinson's disease-related motor deficits by facilitating the MEK-dependent VMAT2 to maintain dopamine homeostasis.

Researchers found that dysregulation of VMAT2 leads to DA neurotoxicity and motor deficits in Parkinson's disease, but treatment with GTD derived from Gastrodia elata Blume may help regulate this dysfunction. This suggests GTD could be a potential treatment for PD.

Zhao M et al (2024).
Phytomedicine.
PubMed:
38885579

Predictive Analysis of Yi-Gai-San's Multifaceted Mechanisms for Tremor-Dominant Parkinson's Disease via Network Pharmacology and Molecular Docking Validation.

YGS treat tremor-dominant Parkinson's by multiple mechanisms. Components analyzed, selected, standardized. Includes Gouteng, Chaihu, Chuanxiong, Danggui, Fuling, Baizhu, Gancao. Important for Parkinson's research and treatment.

Lin CT, Wu LY and Tsai FS (2024).
Curr Med Chem.
PubMed:
38879763

Multi-microdialysis analytical system to monitor acetaminophen and its pharmacokinetic interaction with A. bidentata in rat blood, forelimb extensor muscle, brain striatum, and the knee joint cavity.

Researchers studied the transfer of acetaminophen into various parts of the body when used alone or with a traditional Chinese medicinal herb. Results show no significant difference in pharmacokinetics and suggest broad-range analgesic effects of acetaminophen.

Sun CK et al (2024).
J Pharm Biomed Anal.
PubMed:
38878452

Optimization of Parkinson's disease therapy with plant extracts and nutrition's evolving roles.

Review on the potential of nutrition and plant extracts in managing Parkinson's disease (PD) symptoms. Highlights role in neuroprotection, targeting multiple pathways implicated in PD. Challenges in translating findings into clinical practice discussed. Important for improving quality of life for PD patients.

Abolarin PO et al (2024).
IBRO Neurosci Rep.
PubMed:
38872839

Neuroprotective Action of Selected Natural Drugs Against Neurological Diseases and Mental Disorders: Potential Use Against Radiation Damage.

This review discusses how radiation exposure affects the brain and neurodegenerative diseases. Herbal medicines like Allium cepa and Centella asiatica show promise in protecting against neurological damage and may have potential in managing neurological illnesses.

Akhlada et al (2024).
Neurochem Res.
PubMed:
38864943

Blackberry extract prevents lipopolysaccharide-induced depressive-like behavior in female mice: implications for redox status, inflammation, and brain enzymes.

Blackberry extract showed antidepressant, antioxidant, anticholinesterase, and anti-inflammatory effects in mice with depression induced by LPS. Potential therapy for major depressive disorder.

Custódio SV et al (2024).
Nutr Neurosci.
PubMed:
38861649