Schott leaves show neuroprotective activity in rats, with 16 polyphenolic compounds identified in -BF and 15 in ME. Isolated compounds bind at target pocket with higher energy. These findings reveal new potential treatments for neurological diseases.
Researchers investigated the neuroprotective effects of extract on retinal ganglion cells in a glaucoma rat model. Results show potential for novel neurotherapeutics to treat glaucoma by reducing oxidative stress and remodeling matrix metalloproteinases.
Researchers found that Lactuc extracts improved sleep in mice by increasing adenosine A1 receptor and GABA receptor subunit expression in the brain. This suggests Lactuc could be used to develop natural sleep aids.
Study explores antidepressant-like effects of C. asiatica compounds on zebrafish stress model. Madecassoside and asiaticoside show potential in reducing cortisol levels and behavior, offering new treatment possibilities for depression.
Engeletin from Smilax glabra rhizomilax alleviates depression in mice by modulating microglial polarization and suppressing inflammatory pathways. Potential new avenue for antidepressant treatment targeting microglia.
Arctigenin from Arctium lappa plant protects neurons from drug-induced neurotoxicity by preventing ferroptosis through activating SLC7A11-cystine-cysteine axis. Potential novel agent for neuroprotection.
CBD improves cognition and activates microglia shift in AD model mice. It enhances gut barrier, reduces toxic metabolites, and lowers LPS levels, suggesting a potential therapeutic role in AD.
Cyclic peptide Cylic(PIYAG) from Annona squamosa improves spatial memory, reduces inflammation markers, and passes through intestinal barrier. Potential for preventing cognitive decline.