Eucalyptus globulus leaf-isolated isorhapontin serves as a natural insecticide via acetylcholinesterase inhibition.

Researchers evaluated isorhapontin from E. globulus leaves as a natural insecticide by inhibiting AChE. Isorhapontin acted as a competitive inhibitor and showed potential for insecticide development, binding to AChE's active site.

Park JY et al (2024).

Pestic Biochem Physiol.

DOI:

10.1016/j.pestbp.2024.105834

PubMed:

38582576

MS/MS-based molecular networking discovery of sesquiterpenes from Carpesium abrotanoides L. with their cytotoxic and acetylcholinesterase inhibitory activity.

New sesquiterpenes isolated from Carpesium abrotanoides herbs showed moderate cytotoxicity against liver cancer cells and significant acetylcholinesterase inhibition, potentially useful for developing anti-cancer and Alzheimer's disease treatments.

Zhang X et al (2024).

Fitoterapia.

DOI:

10.1016/j.fitote.2024.105947

PubMed:

38570097

Antidepressant and anxiolytic potential of Citrus reticulata Blanco essential oil: a network pharmacology and animal model study.

Study on Blanco essential oil (CBEO) shows fast-acting antidepressant and anxiolytic effects. Identifies active compounds, optimal dosage, and duration for therapy. Important for potential treatment of depression and anxiety.

Khanh Nguyen NP et al (2024).

Front Pharmacol.

DOI:

10.3389/fphar.2024.1359427

PubMed:

38567354

Structural identification and anti-neuroinflammatory effect of a heteropolysaccharide ATP50-3 from Acorus tatarinowii rhizome.

Crude polysaccharide AT50 from Acorus tatarinowii improves memory and reduces neuroinflammation in Alzheimer's disease mice. Novel heteropolysaccharide ATP50-3 inhibits proinflammatory factors, showing potential for AD treatment.

Yu Q et al (2024).

Int J Biol Macromol.

DOI:

10.1016/j.ijbiomac.2024.131254

PubMed:

38565362

Untargeted metabolomics reveals intervention effects of wine-processed Schisandra chinensis polysaccharide on Alzheimer's disease mice.

Wine-processed Schisandra chinensis polysaccharide improves memory, reduces neuronal damage, and decreases Aβ deposition in AD mice. It also regulates metabolic disorders and shows potential as a treatment for Alzheimer's Disease.

Lun W et al (2024).

Int J Biol Macromol.

DOI:

10.1016/j.ijbiomac.2024.130804

PubMed:

38565361

Investigation of the Cognitive Activity Between the Leaf Extracts of Eclipta alba and Ziziphus jujuba in Diabetic Animal Models.

Study tested ZJ and EA extracts on diabetic rats, showed cognitive improvement in Morris water maze test. Potential cognitive enhancers and hypoglycemic agents in diabetes management.

Annepaka ER et al (2024).

Cureus.

DOI:

10.7759/cureus.55400

PubMed:

38562322

Structural characterization of a galactoglucomannan with anti-neuroinflammatory activity from Ganoderma lucidum.

Researchers isolated a polysaccharide from Ganoderma lucidum, GLP70-1-2, which improved spatial learning and memory, reduced anxiety in an Alzheimer's disease model, and decreased inflammatory factors in cells. GLP70-1-2 shows potential as a drug for Alzheimer's disease.

Cao C et al (2024).

Carbohydr Polym.

DOI:

10.1016/j.carbpol.2024.122030

PubMed:

38553228

Gastrodin regulates the TLR4/TRAF6/NF-κB pathway to reduce neuroinflammation and microglial activation in an AD model.

Wang W et al (2024).

Phytomedicine.

DOI:

10.1016/j.phymed.2024.155518

PubMed:

38552431