Neuroscience Studies

Gossypetin targets the liver-brain axis to alleviate pre-existing liver fibrosis and hippocampal neuroinflammation in mice.

Researchers found gossypetin, a compound from sedum, effectively treats liver fibrosis and related brain issues in mice. It targets liver-brain axis, reducing liver damage and neuroinflammation. Potential therapy for chronic liver patients with neurological symptoms.

Xu C et al (2024).
Front Pharmacol.
PubMed:
38860164

Gastrodin Ameliorates Post-Stroke Depressive-Like Behaviors Through Cannabinoid-1 Receptor-Dependent PKA/RhoA Signaling Pathway.

Research showed that the herbal extract gastrodin relieved depression in stroke patients by restoring synaptic proteins and spine density in the brain. This effect is mediated by CB1R, PKA, and RhoA signaling pathways, suggesting Gas could be a potential treatment for post-stroke depression.

Wang S et al (2024).
Mol Neurobiol.
PubMed:
38856794

Tinospora cordifolia Extract Enhances Dextromethorphan Bioavailability: Implications for Alzheimer's Disease.

Study investigated stem extract potential improve dextromethorphan bioavailability for Alzheimer's disease management. Network pharmacology analysis showed TCE targeting AD factors, enhancing memory and reducing hyperactivity in rodents.

Majhi PK et al (2024).
ACS Omega.
PubMed:
38854540

Integrated spatial metabolomics and network pharmacology to explore the pharmacodynamic substances and mechanism of Radix ginseng-Schisandra chinensis Herb Couple on Alzheimer's disease.

Study using AFADESI-MSI & network pharmacology analyzed RS effects in AD mice. RS attenuated hippocampal damage, impacting 28 biomarkers linked to AD pathophysiology. Shows potential of TCM in understanding herbal formulas for AD treatment.

Fan Y et al (2024).
Anal Bioanal Chem.
PubMed:
38853180

Polysaccharides from Eucommia ulmoides Oliv. leaves alleviates alcohol-induced mouse brain injury and BV-2 microglial dysfunction.

EULP from Eucommia ulmoides leaves protects against acute alcohol-induced brain injury by improving neurobehavioral deficits, neurotransmitter damage, and microglial dysfunction. Consider employing EULP as a potential therapeutic agent for alcohol-induced brain damage.

Li Y et al (2024).
Int J Biol Macromol.
PubMed:
38851621

Pharmacokinetic study and neuropharmacological effects of Atractylenolide Ⅲ to improve cognitive impairment via PI3K/AKT/GSK3β pathway in intracerebroventricular-streptozotocin rats.

Researchers studied the effects of ATL III, a compound in Chinese herb Atractylodes macrocephala Koidz, on neuroinflammation and oxidative stress in relation to Alzheimer's disease. Results suggest potential therapeutic benefits.

Liu G et al (2024).
J Ethnopharmacol.
PubMed:
38838925

Transfer of preclinical study data on the influence of cimicifuga racemosaon functional changes in the hippocampus during menopause.

Black cohosh extract (iCR) may help relieve menopausal symptoms, including hot flashes and cognitive impairments, in women who cannot or prefer not to use hormone replacement therapy. It works by affecting gene expression in the brain, especially in the hippocampus, to regulate various physiological and cognitive functions.

Stute P, Henneicke-von Zepelin HH and Nicken P (2024).
Gynecol Endocrinol.
PubMed:
38833172

α-Glucosidase, butyrylcholinesterase and acetylcholinesterase inhibitory activities of phenolic compounds from Carthamus tinctorius L. flowers: In silico and in vitro studies.

Scientists found seven metabolites in L. flowers with potential benefits for Alzheimer's disease and hyperglycemia. Compounds showed promising inhibitory effects on key enzymes and antioxidant activity. Worth exploring for potential therapeutic applications.

Alotaibi JAM et al (2024).
Saudi Pharm J.
PubMed:
38831925