Neuroscience Studies

Feasibility and Preliminary Efficacy of American Elderberry Juice for Improving Cognition and Inflammation in Patients with Mild Cognitive Impairment.

Elderberry juice may improve cognitive flexibility and reduce inflammation in patients with mild cognitive impairment. Larger studies needed to confirm benefits.

Curtis AF et al (2024).
Int J Mol Sci.
PubMed:
38673938

Arjunolic acid ameliorates lipopolysaccharide-induced depressive behavior by inhibiting neuroinflammation via microglial SIRT1/AMPK/Notch1 signaling pathway.

ARG, derived from Akebia trifoliata, shows anti-inflammatory and neuroprotective effects. Its ability to treat depression by modulating neuroinflammation, serotonin levels, and neurogenesis warrants further study.

Yang Y et al (2024).
J Ethnopharmacol.
PubMed:
38670408

Acute effects of mango leaf extract on cognitive function in healthy adults: a randomised, double-blind, placebo-controlled crossover study.

Study found that mango leaf extract enhances cognitive function and mood in healthy adults. Contains high levels of mangiferin, a polyphenol compound with medicinal properties. Consider using MLE in lab for cognitive enhancement.

Dodd FL et al (2024).
Front Nutr.
PubMed:
38665302

Phyllanthus emblica Fruit Improves Obesity by Reducing Appetite and Enhancing Mucosal Homeostasis via the Gut Microbiota-Brain-Liver Axis in HFD-Induced Leptin-Resistant Rats.

Researchers found that a water extract of L. fruit effectively reduced leptin resistance in high-fat diet fed rats by improving gut barrier function, appetite regulation, and lipid metabolism. This may help in managing obesity and related complications.

Chang HY et al (2024).
J Agric Food Chem.
PubMed:
38659208

Ginkgo biloba and Its Chemical Components in the Management of Alzheimer's Disease.

Chinese medicine compound Gb has promising effects on Alzheimer's disease, offering alternative treatment options. Bioactive plant ingredients can provide antioxidant, anti-inflammatory benefits and improve symptoms. Consider Gb extracts as a potential therapy for neurodegenerative diseases like AD.

Peng Y et al (2024).
Am J Chin Med.
PubMed:
38654507

Acorus calamus Linn.: A novel neuroprotective approach for traumatic brain injury in Drosophila melanogaster.

Researchers studied novel therapies that target specific pathways involved in secondary injury progression following TBI. Understanding these pathways may lead to improved treatments that can halt ongoing damage, reducing mortality and morbidity associated with TBI.

Kalra S et al (2024).
Brain Res.
PubMed:
38643931

Leonurus japonicus Houtt. modulates neuronal apoptosis in intracerebral hemorrhage: Insights from network pharmacology and molecular docking.

Chinese motherwort (Leonurus japonicus) has various medicinal properties including diuretic, hypoglycemic, and neuroprotective effects. It is included in the Chinese Pharmacopoeia and may have potential in treating neuronal apoptosis caused by intracerebral hemorrhage. Importance: potential neuroprotective effects against brain injury.

Wu JW et al (2024).
J Ethnopharmacol.
PubMed:
38642624

Dl-3-n-Butylphthalide Improves Stroke Outcomes after Focal Ischemic Stroke in Mouse Model by Inhibiting the Pyroptosis-regulated Cell Death and Ameliorating Neuroinflammation.

NBP reduces brain damage in mice with stroke, improves neurological function, and decreases inflammation. Potential treatment for human ischemic stroke by targeting pyroptosis and neuroinflammation.

Ge M et al (2024).
Eur J Pharmacol.
PubMed:
38636800