Neuroscience Studies

Ligustilide inhibits Purkinje cell ferritinophagy via the ULK1/NCOA4 pathway to attenuate valproic acid-induced autistic features.

Researchers investigated the potential of Ligustilide (LIG) in treating autism-like symptoms. LIG, extracted from herbs, may be effective in neurological disorders, but its impact on autism remains unknown. This study explores its therapeutic potential for ASD.

Zhou L et al (2024).
Phytomedicine.
PubMed:
38394737

The role of stinging nettle (Urtica dioica L.) in the management of rotenone-induced Parkinson's disease in rats.

Stinging Nettle supplement showed neuroprotective effects in a rat model of Parkinson's disease, reducing apoptosis, inflammation, oxidative stress, and improving clearance of alpha-synuclein deposits. Nettle could be a promising treatment for PD.

Albadawi E et al (2024).
Tissue Cell.
PubMed:
38387425

Gastrodia elata polysaccharide alleviates Parkinson's disease via inhibiting apoptotic and inflammatory signaling pathways and modulating the gut microbiota.

GEP from is a potential treatment for Parkinson's disease, reducing motor dysfunction and neuroinflammation by preventing apoptosis and regulating gut microbiota. Promising for future functional products.

Gan QX et al (2024).
Food Funct.
PubMed:
38385354

E. globulus leaf EO exhibits anti-inflammatory effects by regulating GSDMD-mediated pyroptosis, thereby alleviating neurological impairment and neuroinflammation in experimental stroke mice.

Researchers studied the chemical composition and anti-inflammatory properties of Eucalyptus globulus leaf essential oil from China. This plant is widely used in alternative medicine in developing countries.

Wang D et al (2024).
J Ethnopharmacol.
PubMed:
38380569

Black seed oil reverses chronic antibiotic-mediated depression and social behaviour deficits via modulation of hypothalamic mitochondrial-dependent markers and insulin expression.

Chronic antibiotics can harm mitochondria, metabolism, and mood. Black seed oil improves depression, sociability, and metabolism in mice exposed to ampicillin. NSO could be a helpful treatment for antibiotic-induced impairments.

Adedokun MA et al (2024).
IBRO Neurosci Rep.
PubMed:
38379607

Abietane diterpenoids with anti-neuroinflammation activity from Rosmarinus officinalis.

Tossers identified new abietane diterpenoids in Rosemary, including rosmarinusin Q, showing anti-neuroinflammatory properties. Potential for neuroprotective agents against nerve damage from inflammation.

Zhou T et al (2024).
Fitoterapia.
PubMed:
38378134

Neuroprotective aftermath of Monodora myristica and Glycyrrhiza glabra against cassava diet containing vacuum gas oil induced brain injury in Wistar rats.

Study on neuroprotective effects of plant extracts on rats exposed to vacuum gas oil in their diet. Shows potential to counteract negative neurological effects of VGO consumption. Utilizes biochemical assays to evaluate antioxidant and lipid levels in the brain.

Okpoghono J, Ukperegbulem JK and Onyesom I (2024).
Toxicol Rep.
PubMed:
38375414

The basic chemical substances of total alkaloids of Uncaria rhynchophylla and their anti-neuroinflammatory activities.

Scientists identified new alkaloids in , which showed promising anti-neuroinflammatory effects by inhibiting NO production in microglial cells. Compounds , , , , , , and were particularly effective, with IC values of 5.87-76.78 M.

Qin JX et al (2024).
J Asian Nat Prod Res.
PubMed:
38373226