MdbHLH93 confers drought tolerance by activating MdTyDC expression and promoting dopamine biosynthesis.

Drought stress-induced MdbHLH93 expression positively regulates MdTyDC, leading to dopamine synthesis and enhanced drought tolerance in apples. Increased dopamine content promotes drought tolerance.

Liu X et al (2023).

Int J Biol Macromol.

DOI:

10.1016/j.ijbiomac.2023.129003

PubMed:

38159695

Piperine promotes PI3K/AKT/mTOR-mediated gut-brain autophagy to degrade α-Synuclein in Parkinson's disease rats.

Scientists studied the herb Piper longum and its main compound, piperine, to understand how it protects against Parkinson's disease. They found that piperine promotes a process called autophagy, which helps degrade harmful proteins in the gut and brain. This research may lead to new treatments for Parkinson's disease.

Yu L et al (2023).

J Ethnopharmacol.

DOI:

10.1016/j.jep.2023.117628

PubMed:

38158101

Mercury chloride causes cognitive impairment, oxidative stress and neuroinflammation in male Wistar rats: The potential protective effect of 6-gingerol-rich fraction of Zingiber officinale via regulation of antioxidant defence system and reversal of pro-inflammatory markers increase.

Asuku AO et al (2024).

Brain Res.

DOI:

10.1016/j.brainres.2023.148741

PubMed:

38157955

Volatile oil of Angelica sinensis Radix improves cognitive function by inhibiting miR-301a-3p targeting Ppp2ca in cerebral ischemia mice.

Researchers investigated the effects of Angelica Sinensis Radix (ASR) and its volatile oil (VOASR) on cognitive impairment. ASR is a Chinese medicine used for pain relief and menstrual regulation, while VOASR showed promise in improving cognitive function. Understanding their mechanisms could aid in developing treatments for cognitive impairments.

Zhao J et al (2023).

J Ethnopharmacol.

DOI:

10.1016/j.jep.2023.117621

PubMed:

38154524

Structurally diverse stilbenes from Gnetum parvifolium and their anti-neuroinflammatory activities.

Scientists isolated 15 new and eight known stilbenes from Gnetum parvifolium. These compounds showed significant anti-neuroinflammatory activity, particularly compound 10, which decreased iNOS, IL-1β, IL-6, and TNF-α levels.

Yan QW et al (2023).

Bioorg Chem.

DOI:

10.1016/j.bioorg.2023.107060

PubMed:

38154389

Kaempferol-3-O-(2″-O-galloyl-β-D-glucopyranoside): a novel neuroprotective agent from Diospryros kaki against cerebral ischemia-induced brain injury.

Diospyros kaki L.f. leaf extract contains a potent flavonoid compound (9) that reduces brain injury, improves impairments, preserves blood-brain barrier, and suppresses oxidative stress, suggesting its potential for treating ischemic-induced brain damage.

Nguyen LTT et al (2023).

J Nat Med.

DOI:

10.1007/s11418-023-01765-z

PubMed:

38143256

Neuroprotection and Mechanism of Gas-miR36-5p from Gastrodia elata in an Alzheimer's Disease Model by Regulating Glycogen Synthase Kinase-3β.

Researchers found that a specific miRNA from a traditional Chinese medicine targets GSK-3β, a key factor in Alzheimer's disease. This miRNA showed neuroprotective effects in cell and mouse models. Their findings offer insights into potential treatments for Alzheimer's disease.

Lu Z et al (2023).

Int J Mol Sci.

DOI:

10.3390/ijms242417295

PubMed:

38139125

Mediterranean Shrub Species as a Source of Biomolecules against Neurodegenerative Diseases.

Mediterranean plant species contain phenolic compounds with potential to treat neurodegenerative diseases. 24 species studied, yielding 403 compounds, including gallic, vanillic, caffeic. 3 species show promise for protection against these diseases.

Chaves N et al (2023).

Molecules.

DOI:

10.3390/molecules28248133

PubMed:

38138621