Neuroscience Studies

The Inhibition of Mitogen-Activated Protein Kinases (MAPKs) and NF-κB Underlies the Neuroprotective Capacity of a Cinnamon/Curcumin/Turmeric Spice Blend in Aβ-Exposed THP-1 Cells.

A spice blend of cinnamon bark and turmeric root extracts (CCSB) showed strong antioxidant properties and reduced inflammation in brain cells exposed to β-amyloid. It has potential as a treatment for Alzheimer's disease.

Maugeri A et al (2023).
Molecules.
PubMed:
38138438

Betula pendula Leaf Extract Targets the Interplay between Brain Oxidative Stress, Inflammation, and NFkB Pathways in Amyloid Aβ(1-42)-Treated Rats.

Researchers analyzed a leaf extract for its chemical composition and tested its effects on rats with Alzheimer's disease (AD). The extract reduced oxidative stress and inflammation, improved antioxidant capacity, and enhanced behavior, suggesting potential benefits for AD treatment.

Sevastre-Berghian AC et al (2023).
Antioxidants (Basel).
PubMed:
38136229

Effect of multicomponent crystal of piperine-nicotinic acid on antihyperlipidemic activity in rats.

The study shows that multicomponent crystals of piperine-nicotinic acid reduced total cholesterol, triglyceride, and LDL cholesterol levels while increasing HDL cholesterol levels in high-fat diet-fed rats.

Octavia MD et al (2023).
Pak J Pharm Sci.
PubMed:
38124418

The methanolic extract of Hibiscus sabdariffa downregulates the relative expression of Kiss1 gene in the hypothalamus of Wistar rats: A preliminary report.

Researchers studied the effects of a plant extract on gene expression in the rat hypothalamus. This extract may regulate a gene that controls the reproductive system, providing insights into its potential as a fertility regulator.

Okafor IA et al (2023).
Avicenna J Phytomed.
PubMed:
38106630

Assessment of the neuroprotective effect of Cocos nucifera L. oil on learning and behavior impairment in ovariectomized rats.

Study investigated the effect of L. oil on memory of menopausal rats. Findings could help address memory issues in menopausal individuals.

Balderan A et al (2023).
Avicenna J Phytomed.
PubMed:
38106629

Biogenic synthesis of dopamine/carboxymethyl cellulose/TiO(2) nanoparticles using Psidium guajava leaf extract with enhanced antimicrobial and anticancer activities.

Researchers synthesized titanium oxide (TiO) and dopamine (DA)/carboxymethyl cellulose (CMC)-doped TiO nanoparticles (NPs) using Psidium guajava leaf extract. The NPs showed larger zones of inhibition against pathogens and higher anticancer activity compared to TiO NPs. These findings suggest the potential of DA/CMC/TiO NPs for various applications.

Ganapathy K et al (2023).
Bioprocess Biosyst Eng.
PubMed:
38103080

Azadiradione up-regulates the expression of parvalbumin and BDNF via Ube3a.

The compound azadiradione found in Neem seeds has shown potential in improving synaptic function by increasing expression of Ube3a, parvalbumin, and BDNF. This suggests a possible role in treating neuropsychiatric/neurodegenerative disorders.

Jana S et al (2023).
Gene.
PubMed:
38101713

Higenamine exerts antidepressant effect by improving the astrocytic gap junctions and inflammatory response.

Researchers investigated the effects of higenamine, found in Fuzi herb, on depression. Higenamine improved the dysfunction of gap junctions between astrocytes and reduced neuroinflammation. This suggests higenamine may be a potential treatment for neuropsychiatric disorders, including depression.

Yao J et al (2023).
J Affect Disord.
PubMed:
38101523