Neuroscience Studies

Antidepressant effects of 70% ethanolic extract of Lonicerae japonicae flos and it contained chlorogenic acid via upregulation of BDNF-TrkB pathway in the hippocampus of mice.

Lonicera japonica flos (LJF) extract and chlorogenic acid (CGA) show significant antidepressant effects, correlating with CGA content. LJF-70% ethanolic extract and CGA improve depressive behavior, upregulate BDNF-TrkB pathway, restore hippocampal neurons, and protect the liver.

Neuroscience Lonicera japonica
Qin L et al (2023).
Brain Res Bull.
DOI:
10.1016/j.brainresbull.2023.110796
PubMed:
37863440

Valerenic acid reduces anxiety-like behavior in young adult, female (C57BL/6J) mice.

Valeriana officinalis extract contains valerenic acid (VA) and is believed to treat anxiety and insomnia. In this study, VA was shown to have similar anxiety-reducing effects as diazepam without affecting locomotor activity or inducing depression-like behavior. VA could potentially be used as an anxiolytic drug.

Neuroscience Valeriana officinalis
Pinder NE et al (2023).
Behav Brain Res.
DOI:
10.1016/j.bbr.2023.114717
PubMed:
37852540

Neuroprotective effects of a combination of Boswellia papyrifera and Syzygium aromaticum on AlCl3 induced Alzheimer's disease in male albino rat.

Combination therapy of Boswellia papyrifera and Syzygium aromaticum improved cognitive function, increased acetylcholinesterase and oxidative enzyme levels, and reduced oxidative stress markers in Alzheimer's disease, offering potential treatment.

Neuroscience Syzygium aromaticum
Aljarari RM et al (2023).
Braz J Biol.
DOI:
10.1590/1519-6984.272466
PubMed:
37851769

Cannabinoids and endocannabinoids as therapeutics for nervous system disorders: preclinical models and clinical studies.

Cannabinoids from Cannabis sativa have therapeutic potential for CNS diseases. This review summarizes their effects in cellular, animal, and human trials, suggesting their use for neurological disorders.

Neuroscience Cannabis sativa
Duncan RS et al (2024).
Neural Regen Res.
DOI:
10.4103/1673-5374.382220
PubMed:
37843213

Aromatic glycosides and lignans glycosides with their acetylcholinesterase inhibitory activities from the leaves of Picrasma quassioides.

In this study, researchers isolated eight new natural products from Picrasma quassioides leaves. They determined their structures and found that compound 6 showed weak inhibitory activity against acetylcholinesterase, which could be relevant for Alzheimer's disease. Molecular docking illustrated the interaction between compound 6 and AChE active sites.

NeurosciencePhytochemistry Picrasma quassioides
Jia Q et al (2023).
Fitoterapia.
DOI:
10.1016/j.fitote.2023.105701
PubMed:
37832877

Harder, better, faster, stronger? Retrospective chart review of adverse events of interactions between adaptogens and antidepressant drugs.

This study evaluated the prevalence and characteristics of adverse events associated with adaptogen-antidepressant interactions. Adaptogens were involved in 9% of adverse events. Clinicians should monitor these interactions due to the potential for clinically significant adverse events.

Neuroscience Cimicifuga racemosaEleutherococcus senticosusGynostemma pentaphyllumTribulus terrestrisWithania somnifera
Siwek M et al (2023).
Front Pharmacol.
DOI:
10.3389/fphar.2023.1271776
PubMed:
37829299

The extract of Sclerocarya birrea, Nauclea latifolia, and Piper longum mixture ameliorates diabetes-associated cognitive dysfunction.

A mixture of Sclerocarya birrea, Nauclea latifolia, and Piper longum (SNP) improved blood glucose levels, protected neurons, and improved memory in diabetic rats by reducing oxidative stress, inflammation, and acetylcholinesterase activity.

DiabetesNeuroscience Piper longumSclerocarya birrea
Tientcheu JPD et al (2023).
Metab Brain Dis.
DOI:
10.1007/s11011-023-01291-7
PubMed:
37821784

Therapeutic Effects of Geranium Oil in MPTP-Induced Parkinsonian Mouse Model.

Geranium oil improved motor performance and prevented neuron death in a Parkinson's disease (PD) mouse model. Its antioxidant and anti-inflammatory properties suggest it could be a safe treatment for PD, but more research is needed to confirm its effectiveness.

Neuroscience Pelargonium graveolens
Telerman A et al (2023).
Plant Foods Hum Nutr.
DOI:
10.1007/s11130-023-01112-3
PubMed:
37819493
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