Liensinine and neferine exert neuroprotective effects via the autophagy pathway in transgenic Caenorhabditis elegans.

Liensinine and neferine, found in Nelumbo nucifera, inhibit acetylcholinesterase and cross the blood-brain barrier. They hold promise for treating Alzheimer's disease.

Wu MC et al (2023).

BMC Complement Med Ther.

DOI:

10.1186/s12906-023-04183-6

PubMed:

37891552

Developmental landscape of computational techniques to explore the potential phytochemicals from Punica granatum peels for their antioxidant activity in Alzheimer's disease.

Researchers prepared and studied a library of 1,000 compounds from peels to find antioxidants for Alzheimer's disease. Using computational calculations, they identified active compounds and performed molecular docking, optimization, and toxicity evaluation. Hesperidin showed promise as a potential drug for Alzheimer's treatment.

Parveen S et al (2023).

Front Mol Biosci.

DOI:

10.3389/fmolb.2023.1252178

PubMed:

37886033

A Standardized Withania somniferra (Linn.) Root Extract with Piperine Alleviates the Symptoms of Anxiety and Depression by Increasing Serotonin Levels: A Double-Blind, Randomized, Placebo-Controlled Study.

Ashwagandha root extract with standardized withanolides and piperine improved depression, anxiety, sleep quality, and quality of life compared to placebo. It increased serotonin levels and was well-tolerated.

Majeed M et al (2023).

J Integr Complement Med.

DOI:

10.1089/jicm.2023.0279

PubMed:

37878284

Dietary Supplement with Tribulus terrestris L. Extract Exhibits Protective Effects on Ischemic Stroke Rats.

Researchers found that gross saponins of Tribulus terrestris extract have a protective effect against ischemic stroke, although the mechanism is not fully understood. Relevant for potential stroke prevention strategies.

Guo W et al (2023).

Mol Nutr Food Res.

DOI:

10.1002/mnfr.202300447

PubMed:

37876150

In Vitro and In Vivo Supplementation with Curcumin Promotes Hippocampal Neuronal Synapses Development in Rats by Inhibiting GSK-3β and Activating β-catenin.

Zhang Y et al (2023).

Mol Neurobiol.

DOI:

10.1007/s12035-023-03665-5

PubMed:

37875709

Acute effects of a chewable beetroot-based supplement on cognitive performance: a double-blind randomized placebo-controlled crossover clinical trial.

Researchers studied the effects of dietary nitrate and beetroot juice on cognitive function. Results are inconclusive, but understanding these effects can benefit health and disease management.

Vaccaro MG et al (2023).

Eur J Nutr.

DOI:

10.1007/s00394-023-03265-y

PubMed:

37875637

Neurotoxicity study of ethyl acetate extract of Zanthoxylum armatum DC. on SH-SY5Y based on ROS mediated mitochondrial apoptosis pathway.

ZADC is a plant used medicinally but its methanol extract causes neurotoxicity in rats. However, the specific toxic substances and the mechanism of neurotoxicity are still unknown.

Guo J et al (2023).

J Ethnopharmacol.

DOI:

10.1016/j.jep.2023.117321

PubMed:

37866465

The Effects of Crocus sativus (Saffron) on ADHD: A Systematic Review.

Study evaluated saffron extracts for ADHD treatment, assessing effectiveness and safety. Important for lab decisions due to saffron's popularity and potential as a traditional plant remedy.

Seyedi-Sahebari S et al (2023).

J Atten Disord.

DOI:

10.1177/10870547231203176

PubMed:

37864351