Use of double-stranded RNA targeting β2 divergent nicotinic acetylcholine receptor subunit to control pea aphid Acyrthosiphon pisum at larval and adult stages.

Ligonniere S, Raymond V and Goven D (2024).

Pest Manag Sci.

DOI:

10.1002/ps.7820

PubMed:

37816139

Structurally diverse terpenoids from Elephantopus scaber L. and their acetylcholinesterase inhibitory activities.

Researchers isolated three new compounds, elephantopuscabers A-C, and a known compound spirowallichiione from Elephantopus scaber L. Their structures were determined using extensive analysis techniques. Elephantopuscaber B and C showed potential as acetylcholinesterase inhibitors. Molecular docking predicted the binding sites.

Li JY et al (2023).

Phytochemistry.

DOI:

10.1016/j.phytochem.2023.113892

PubMed:

37813132

Evaluating the role of Ginkgo biloba extract in the secondary prevention of Acute Ischemic Stroke with cerebral microbleeds by Quantitative Susceptibility Mapping（QSM）.

EGb 761, a Ginkgo biloba extract, has anti-inflammatory and thrombotic effects. In a study, EGb combined with Aspirin improved blood oxygen saturation in ischemic stroke patients with microbleeds. This combo could be effective for long-term secondary prevention.

Lan W et al (2023).

Int J Neurosci.

DOI:

10.1080/00207454.2023.2268264

PubMed:

37812205

Petroselinum crispum Extract Prevents Lens Damage in Scopolamine-Induced Cognitive Dysfunction.

Parsley extract reduces oxidative stress on lens tissue in rats with Alzheimer's disease, suggesting potential for herbal AD treatments with fewer side effects.

Ertik O et al (2023).

Chem Biodivers.

DOI:

10.1002/cbdv.202300776

PubMed:

37811911

Evaluation of berberine nanoparticles as a strategy to modulate acetylcholinesterase activity.

Berberine-loaded solid dispersions (SD) show potential as inhibitors of acetylcholinesterase enzyme (AChE) for neurodegenerative disease treatment, with improved water solubility and cytotoxic effects on tumoral cells. The berberine SD also demonstrated no cytotoxicity/genotoxicity in testing, suggesting it could be a safe option.

Leimann FV et al (2023).

Food Res Int.

DOI:

10.1016/j.foodres.2023.113295

PubMed:

37803607

Koumine ameliorates neuroinflammation by regulating microglia polarization via activation of Nrf2/HO-1 pathway.

Gelsemium elegans, a traditional medicine, contains Koumine, which can reduce inflammation by modulating macrophage activation and polarization. This research might have potential applications in treating inflammatory conditions.

Wang L et al (2023).

Biomed Pharmacother.

DOI:

10.1016/j.biopha.2023.115608

PubMed:

37801902

Neuroprotective Effect of Ethanolic Extract of Scoparia dulcis on Acrylamide-Induced Neurotoxicity in Zebrafish Model.

Scoparia dulcis, an herbal medicine, was tested on zebrafish to study its neuroprotective effects against acrylamide-induced neurotoxicity. EESD improved memory and mitigated toxicity, showing potential as a neuroprotective agent.

Raghunathan T, Srinivasan S and Jamuna S (2023).

Appl Biochem Biotechnol.

DOI:

10.1007/s12010-023-04733-1

PubMed:

37801272

Engeletin alleviates depression-like phenotype by increasing synaptic plasticity via the BDNF-TrkB-mTORC1 signalling pathway.

Engeletin from Smilax glabra shows antidepressant-like effects in mice by activating the BDNF-TrkB-mTORC1 pathway, enhancing synaptic plasticity in the prefrontal cortex. Promising as a new antidepressant.

Xu Y et al (2023).

J Cell Mol Med.

DOI:

10.1111/jcmm.17975

PubMed:

37799103