GeoBotanical: Neuroscience Studies

329.

Salvianolic acid A provides neuroprotective effects on cerebral ischemia-reperfusion injury in rats via PKA/CREB/c-Fos signaling pathway.

Researchers investigated the neuroprotective properties of salvianolic acid A (SAA) in cerebral ischemia-reperfusion injury (CIRI). SAA, derived from Salvia miltiorrhiza Bge., shows potential in treating brain injury, but its mechanisms of action are not fully understood.

Cardiology Neuroscience Salvia

Yang R et al (2024).; Phytomedicine.
DOI:: 10.1016/j.phymed.2023.155326
PubMed:: 38185068

330.

Exploration of neuroprotective effect from Coriandrum sativum L. ethanolic seeds extracts on brain of obese rats.

Coriander seed extract was given to obese rats for 12 weeks. It reduced oxidative stress and cellular senescence markers, while increasing antioxidants. It could be a neuroprotective agent.

Neuroscience Obesity Coriandrum sativum

Hardiany NS et al (2024).; Sci Rep.
DOI:: 10.1038/s41598-024-51221-5
PubMed:: 38182767

331.

Protective role of madecassoside from Centella asiatica against protein L-isoaspartyl methyltransferase deficiency-induced neurodegeneration.

PIMT protein repairs brain protein damage linked to aging. Mice without PIMT showed anxiety and cognitive issues, but treatment with MA reversed symptoms. MA could help treat anxiety and cognitive impairments in neurodegenerative diseases.

Neuroscience Centella asiatica

Ling Z et al (2024).; Neuropharmacology.
DOI:: 10.1016/j.neuropharm.2023.109834
PubMed:: 38181970

332.

Protective effect of a hydromethanolic extract from Fraxinus excelsior L. bark against a rat model of aluminum chloride-induced Alzheimer's disease: Relevance to its anti-inflammatory and antioxidant effects.

Fraxinus excelsior (ash) has various beneficial properties including antioxidant and anti-inflammatory effects. It has been traditionally used to treat neurological disorders. This study investigates its potential effectiveness in Alzheimer's disease, which involves amyloid-beta, oxidative stress, and neuroinflammation.

Immunology Neuroscience Fraxinus excelsior

Iranpanah A et al (2024).; J Ethnopharmacol.
DOI:: 10.1016/j.jep.2024.117708
PubMed:: 38181932

333.

Combination of Atractylenolide I, Atractylenolide III, and Paeoniflorin promotes angiogenesis and improves neurological recovery in a mouse model of ischemic Stroke.

Study investigated the effects of Atractylenolide I, Atractylenolide III, and Paeoniflorin on promoting angiogenesis after stroke. Findings could contribute to potential therapies for improving outcomes in stroke patients.

Cardiology Neuroscience Atractylodes macrocephala

Li H et al (2024).; Chin Med.
DOI:: 10.1186/s13020-023-00872-z
PubMed:: 38178130

334.

Hypericum perforatum: a comprehensive review on pharmacognosy, preclinical studies, putative molecular mechanism, and clinical studies in neurodegenerative diseases.

St. John's wort shows promise in treating neurodegenerative diseases due to its anti-inflammatory and antioxidant properties, as well as its ability to regulate neurotransmitter systems. Animal studies have shown improved cognitive performance and nerve cell survival. More research is needed for clinical applications.

Neuroscience Hypericum perforatum

Suryawanshi MV et al (2024).; Naunyn Schmiedebergs Arch Pharmacol.
DOI:: 10.1007/s00210-023-02915-6
PubMed:: 38175276

335.

Rattan Pepper Polysaccharide Regulates DSS-Induced Intestinal Inflammation and Depressive Behavior through Microbiota-Gut-Brain Axis.

This study found that rattan pepper polysaccharide (RPP) can reduce intestinal inflammation and depression-like behavior in mice with inflammatory bowel disease (IBD). RPP improves gut microbiota balance, reduces brain inflammation, and enhances synaptic function. This suggests that RPP may have potential therapeutic effects for IBD and associated depression.

Gastroenterology Immunology Neuroscience Piper nigrum

Chang L et al (2024).; J Agric Food Chem.
DOI:: 10.1021/acs.jafc.3c08462
PubMed:: 38164789

336.

Impact of Codonopsis decoction on cerebral blood flow and cognitive function in rats with chronic cerebral ischemia.

Researchers investigated the use of Codonopsis decoction, a traditional Chinese medicine made from the dried roots of certain species of Codonopsis, in treating chronic cerebral ischemia (CCI). CCI is associated with qi and blood deficiencies and fluid depletion. This study explores the potential benefits and medicinal properties of Codonopsis in CCI treatment.

Cardiology Neuroscience Codonopsis pilosula

Wang J et al (2023).; J Ethnopharmacol.
DOI:: 10.1016/j.jep.2023.117585
PubMed:: 38159825